Aggregation-induced emission: An illuminator in the brain

Duo, Yanhong1,2; Yang, Yaoqiang1; Xu, Tianzhao1; Zhou, Ri4; Wang, Renzhi5; Luo, Guanghong1,2; Tang, Ben Zhong3

2023-05-01

10.1016/j.ccr.2023.215070

COORDINATION CHEMISTRY REVIEWS   影响因子和分区

0010-8545

1873-3840

The brain is the central control hub of the whole body. Hence, the consequences of brain diseases can be lethal. Despite the progress in fundamental and clinical research, several key obstacles remain to be addressed. As an emerging science, aggregation-induced emission (AIE) has attracted great interest in the past few years owing to the overwhelming advantages of AIE luminogens (AIEgens), including their emission wavelength, quantum yield, spatial resolution, photosensitivity, photostability, signal-to-noise ratio, and biocompatibility. Herein, we provide a comprehensive summary of AIEgen applications in brain science, including health evaluation, disease detection, diagnosis, imaging, and therapeutics. The review has been summarized into five sections: i) Penetration of AIEgen-based nanomaterials across biological barriers; ii) Detection and diagnosis of brain diseases with AIEgen; iii) Bioimaging of the brain structure in health and disease with AIEgen; iv) Therapeutics for specific diseases in the brain using AIEgen; v) Future outlooks surrounding the applications of AIEgens in the brain. We hope that this review will promote a deeper understanding of the use of AIEgens in the neuroscience community and inspire additional research aimed at improving the current situation in the clinic. (c) 2023 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Aggregation-induced emission Brain Diagnosis Imaging Therapeutics

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China[82102904] ; Science, Technology & Innovation Commission of Shenzhen Municipality["JCYJ20190807144605514","JCYJ20210324113405014","JCYJ20190- 808154213097","JCYJ20180508151803802"]

Chemistry

Chemistry, Inorganic & Nuclear

WOS:001011379100001

ELSEVIER SCIENCE SA

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Affiliated Hosp 1, Jinan Univ, Shenzhen Peoples Hosp,Clin Med Coll 2,Dept Radiat, Shenzhen 518020, Guangdong, Peoples R China
2.Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, Stockholm, Sweden
3.Chinese Univ Hong Kong, Shenzhen Inst Aggregate Sci & Technol, Sch Sci & Engn, Shenzhen 518172, Guangdong, Peoples R China
4.Sun Yat Sen Univ, Affiliated Hosp 8, Dept Orthoped, Shenzhen 518033, Guangdong, Peoples R China
5.Chinese Univ Hong Kong, Sch Med Life & Hlth Sci, Shenzhen 518172, Guangdong, Peoples R China

Duo, Yanhong,Yang, Yaoqiang,Xu, Tianzhao,et al. Aggregation-induced emission: An illuminator in the brain[J]. COORDINATION CHEMISTRY REVIEWS,2023,482.

Duo, Yanhong.,Yang, Yaoqiang.,Xu, Tianzhao.,Zhou, Ri.,Wang, Renzhi.,...&Tang, Ben Zhong.(2023).Aggregation-induced emission: An illuminator in the brain.COORDINATION CHEMISTRY REVIEWS,482.

Duo, Yanhong,et al."Aggregation-induced emission: An illuminator in the brain".COORDINATION CHEMISTRY REVIEWS 482(2023).