Antibacterial and antibiofilm activities of ZIF-67

Gallegos-Monterrosa, Ramses1; Mendiola, Rodrigo Orozco2; Nunez, Yoselin3; Auvynet, Constance3; Kumar, Kesarla Mohan2; Tang, Bin4; Ruiz-Ortega, Leonardo I.2,5; Bustamante, Victor H.1

2023-06-01

10.1038/s41429-023-00637-8

JOURNAL OF ANTIBIOTICS   影响因子和分区

0021-8820

1881-1469

Currently, antibiotic-resistant bacteria represent a serious threat to public health worldwide. Biofilm formation potentiates both virulence and antibiotic resistance of bacteria. Therefore, the discovery of new antibacterial and antibiofilm compounds is an issue of paramount importance to combat and prevent hard-to-treat bacterial infections. Zeolitic-imidazolate-frameworks (ZIFs) are metallo-organic compounds known to have various interesting chemical and biological applications, including antibacterial properties. In this study, we synthesized ZIF-67 nanoparticles, formed by imidazolate anions and cobalt cations, and found that they inhibit the growth of Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus. Sub-inhibitory concentrations of ZIF-67 were also able to significantly reduce the biomass of pre-established biofilms of these pathogenic bacteria. On the other hand, the ZIF-67 nanoparticles had null or low cytotoxicity in mammalian cells at those concentrations showing antibacterial or antibiofilm activities. Thus, our results reveal the potential of ZIF-67 nanoparticles to be used against pathogenic bacteria.

SCI

英语

其他

CONACYT - Mexico[PN 2017-01-5182] ; PAPIIT - UNAM[IA201321]

Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy

Biotechnology & Applied Microbiology ; Immunology ; Microbiology ; Pharmacology & Pharmacy

WOS:001010670100001

SPRINGERNATURE

PHARMACOLOGY & TOXICOLOGY

Web of Science

1.Univ Nacl Autonoma Mexico, Dept Microbiol Mol, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
2.Univ Nacl Autonoma Mexico, Inst Ciencias Fis, Cuernavaca 62210, Morelos, Mexico
3.Univ Nacl Autonoma Mexico, Dept Med Mol & Bioproc, Inst Biotecnol, Cuernavaca 62210, Morelos, Mexico
4.Southern Univ Sci & Technol, Dept Biomed Engn, 1088 Xueyuan Ave, Shenzhen 518055, Peoples R China
5.Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

Gallegos-Monterrosa, Ramses,Mendiola, Rodrigo Orozco,Nunez, Yoselin,et al. Antibacterial and antibiofilm activities of ZIF-67[J]. JOURNAL OF ANTIBIOTICS,2023,76(10).

Gallegos-Monterrosa, Ramses.,Mendiola, Rodrigo Orozco.,Nunez, Yoselin.,Auvynet, Constance.,Kumar, Kesarla Mohan.,...&Bustamante, Victor H..(2023).Antibacterial and antibiofilm activities of ZIF-67.JOURNAL OF ANTIBIOTICS,76(10).

Gallegos-Monterrosa, Ramses,et al."Antibacterial and antibiofilm activities of ZIF-67".JOURNAL OF ANTIBIOTICS 76.10(2023).