Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain

Chen, Chao1,2; Sun, Linlin3,4; Adler, Avital5; Zhou, Hang3; Zhang, Licheng1; Zhang, Lihai1; Deng, Junhao1; Bai, Yang6; Zhang, Jinhui7; Yang, Guang3; Gan, Wen-Biao6; Tang, Peifu1

2023-02-08

10.1038/s41467-023-36093-z

NATURE COMMUNICATIONS   影响因子和分区

2041-1723

["Increased low frequency cortical oscillations are observed in people with neuropathic pain, but the cause of such elevated cortical oscillations and their impact on pain development remain unclear. By imaging neuronal activity in a spared nerve injury (SNI) mouse model of neuropathic pain, we show that neurons in dorsal root ganglia (DRG) and somatosensory cortex (S1) exhibit synchronized activity after peripheral nerve injury. Notably, synchronized activity of DRG neurons occurs within hours after injury and 1-2 days before increased cortical oscillations. This DRG synchrony is initiated by axotomized neurons and mediated by local purinergic signaling at the site of nerve injury. We further show that synchronized DRG activity after SNI is responsible for increasing low frequency cortical oscillations and synaptic remodeling in S1, as well as for inducing animals' pain-like behaviors. In naive mice, enhancing the synchrony, not the level, of DRG neuronal activity causes synaptic changes in S1 and pain-like behaviors similar to SNI mice. Taken together, these results reveal the critical role of synchronized DRG neuronal activity in increasing cortical plasticity and oscillations in a neuropathic pain model. These findings also suggest the potential importance of detection and suppression of elevated cortical oscillations in neuropathic pain states.","Increased low frequency cortical oscillations are observed in neuropathic pain. Here the authors perform Ca2+ imaging of DRG sensory neurons in a mouse model of neuropathic pain, and show that synchronized activity of DRG neurons occurs within hours after injury and 1-2 days before increased cortical oscillations are observed."]

SCI

英语

NI论文

其他

National Natural Science Foundation of China["82101312","81520108017"] ; Guangdong Natural Science Foundation for Major Cultivation Project[2018B030336001]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:001003115900015

NATURE PORTFOLIO

Web of Science

1.Peking 301 Hosp, Dept Orthopaed, Beijing, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Hand Surg,Clin Med Coll 2,Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
3.Columbia Univ, Med Ctr, Dept Anesthesiol, New York, NY 10027 USA
4.Peking Univ, Neurosci Res Inst, Sch Basic Med Sci, Key Lab Neurosci,Minist Educ,Natl Hlth Commiss Chi, Beijing, Peoples R China
5.NYU, Skirball Inst, Sch Med, Dept Neurosci & Physiol, New York, NY USA
6.Shenzhen Bay Lab, Inst Neurol & Psychiat Disorders, Shenzhen, Guangdong, Peoples R China
7.Xiamen Univ, Zhangzhou Hosp 175, Affiliated Southeast Hosp, Dept Orthopaed, Zhangzhou, Fujian, Peoples R China

Chen, Chao,Sun, Linlin,Adler, Avital,et al. Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain[J]. NATURE COMMUNICATIONS,2023,14(1).

Chen, Chao.,Sun, Linlin.,Adler, Avital.,Zhou, Hang.,Zhang, Licheng.,...&Tang, Peifu.(2023).Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain.NATURE COMMUNICATIONS,14(1).

Chen, Chao,et al."Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain".NATURE COMMUNICATIONS 14.1(2023).