南方科技大学知识苑(SUSTech KC): Divalent Anion-Induced Biohydrogels with High Strength, Anti-swelling, and Bioactive Capability for Enhanced Skull Bone Regeneration

题名	Divalent Anion-Induced Biohydrogels with High Strength, Anti-swelling, and Bioactive Capability for Enhanced Skull Bone Regeneration
作者	You, Ziying 1; Yu, Yue 1; Wang, Tie Hua 2,3; Wang, Chenglin 1; Xiong, Ding 1; Shi, Yu 1; Wang, Zhenming 1; Ye, Ling 1
通讯作者	Wang, Zhenming; Ye, Ling
发表日期	2023-06-01
DOI	10.1021/acsami.3c04729
发表期刊	ACS APPLIED MATERIALS & INTERFACES 影响因子和分区
ISSN	1944-8244
EISSN	1944-8252
卷号	15 期号:26
摘要	Increased intracranial pressure after traumatic braininjury (TBI)is an urgent problem in clinical practice. A pliable hydrogel is preferredfor cranioplasty applications after TBI since it can protect braintissue and promote bone healing. Nevertheless, biohydrogels for cranialbone regeneration still face challenges of poor mechanical properties,large swelling ratios, and low osteogenesis activity. Herein, inspiredby Hofmeister effects, biopolymer hydrogels composed of protein andpolysaccharides were treated with a Hofmeister series including aseries of monovalent and divalent anions. Our results reveal thatthe divalent anion-cross-linked biohydrogels exhibit stronger mechanicalproperties and lower swelling ratios compared with monovalent-aniontreated gels. Intriguingly, the divalent HPO4 (2-) anion induced biohybrid hydrogels with excellent mechanical behaviors(3.7 & PLUSMN; 0.58 MPa, 484 & PLUSMN; 76.7 kPa, and 148.3 & PLUSMN; 6.85 kJ/m(3)), anti-swelling capability (16.7%), and gradual degradationability, significantly stimulating osteogenic differentiation andin vivo cranial bone regeneration. Overall, this study may providenew insights into the design of biomimetic hydrogels for treatingcranial bone defects after TBI.
关键词	Hofmeister effects biohydrogels divalentanions bioactivity cranial bone regeneration
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	National Science Fund for Distinguished Young Scholars of China[81825005] ; Natural Science Foundation of China[81702162] ; Sichuan Provincial Science and Technology Department Project[23NSFSC1755] ; Sichuan International Science and Technology Innovation Cooperation Project of Hong Kong, Macao, and Taiwan[2021YFH0185] ; West China School/Hospital of Stomatology Sichuan University[QDJF2021-1]
WOS研究方向	Science & Technology - Other Topics ; Materials Science
WOS类目	Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号	WOS:001018262500001
出版者	AMER CHEMICAL SOC
来源库	Web of Science
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/549176
专题	南方科技大学第一附属医院
作者单位	1.Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu 610041, Peoples R China 2.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Emergency, Shenzhen 518020, Guangdong, Peoples R China 3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	You, Ziying,Yu, Yue,Wang, Tie Hua,et al. Divalent Anion-Induced Biohydrogels with High Strength, Anti-swelling, and Bioactive Capability for Enhanced Skull Bone Regeneration[J]. ACS APPLIED MATERIALS & INTERFACES,2023,15(26).
APA	You, Ziying.,Yu, Yue.,Wang, Tie Hua.,Wang, Chenglin.,Xiong, Ding.,...&Ye, Ling.(2023).Divalent Anion-Induced Biohydrogels with High Strength, Anti-swelling, and Bioactive Capability for Enhanced Skull Bone Regeneration.ACS APPLIED MATERIALS & INTERFACES,15(26).
MLA	You, Ziying,et al."Divalent Anion-Induced Biohydrogels with High Strength, Anti-swelling, and Bioactive Capability for Enhanced Skull Bone Regeneration".ACS APPLIED MATERIALS & INTERFACES 15.26(2023).