Plant-derived exosomal nanoparticles: potential therapeutic for inflammatory bowel disease

Li, De-feng1,2; Tang, Qi1,2; Yang, Mei-feng3; Xu, Hao-ming4; Zhu, Min-zheng4; Zhang, Yuan5; Tian, Cheng-mei2,6; Nie, Yu-qiang4; Wang, Jian-yao7; Liang, Yu-jie8; Wang, Li-sheng1,2; Yao, Jun1,2

2023-06-01

10.1039/d3na00093a

NANOSCALE ADVANCES   影响因子和分区

2516-0230

Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, is a chronic autoimmune disorder characterized by inflammation. However, currently available disease-modifying anti-IBD drugs exhibit limited efficacy in IBD therapy. Furthermore, existing therapeutic approaches provide only partial relief from IBD symptoms and are associated with certain side effects. In recent years, a novel category of nanoscale membrane vesicles, known as plant-derived exosome-like nanoparticles (PDENs), has been identified in edible plants. These PDENs are abundant in bioactive lipids, proteins, microRNAs, and other pharmacologically active compounds. Notably, PDENs possess immunomodulatory, antitumor, regenerative, and anti-inflammatory properties, making them particularly promising for the treatment of intestinal diseases. Moreover, PDENs can be engineered as targeted delivery systems for the efficient transport of chemical or nucleic acid drugs to the site of intestinal inflammation. In the present study, we provided an overview of PDENs, including their biogenesis, extraction, purification, and construction strategies, and elucidated their physiological functions and therapeutic effects on IBD. Additionally, we summarized the applications and potential of PDENs in IBD treatment while highlighting the future directions and challenges in the field of emerging nanotherapeutics for IBD therapy.

SCI

英语

通讯

Technical Research and Development Project of Shenzhen["JCYJ20150403101028164","JCYC20170307100911479","JCYJ20190807145617113","JCYJ20210324113802006","JCYJ2022053015180024"] ; Shenzhen Fund for Guangdong Provincial High Level Clinical Key Specialties[SZGSP013] ; Shenzhen Key Medical Discipline Construction Fund[SZXK042] ; Guangdong High-level Hospital Construction Fund[ynkt2021-zz07]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:001016279200001

ROYAL SOC CHEMISTRY

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Dept Gastroenterol, Clin Med Coll 2, Guangzhou, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
3.Yantian Dist Peoples Hosp, Dept Hematol, Shenzhen 518020, Guangdong, Peoples R China
4.South China Univ Technol, Guangzhou Peoples Hosp 1, Sch Med, Dept Gastroenterol & Hepatol, Guangzhou 510030, Peoples R China
5.Huizhou Inst Occupat Dis Control & Prevent, Dept Med Adm, Huizhou 516000, Guangdong, Peoples R China
6.Jinan Univ, Shenzhen Peoples Hosp, Dept Emergency, Clin Med Coll 2, Guangzhou, Peoples R China
7.Shenzhen Childrens Hosp, Dept Gen Surg, Shenzhen 518026, Guangdong, Peoples R China
8.Shenzhen Kangning Hosp, Dept Child & Adolescent Psychiat, Shenzhen 518020, Guangdong, Peoples R China

Li, De-feng,Tang, Qi,Yang, Mei-feng,et al. Plant-derived exosomal nanoparticles: potential therapeutic for inflammatory bowel disease[J]. NANOSCALE ADVANCES,2023,5(14).

Li, De-feng.,Tang, Qi.,Yang, Mei-feng.,Xu, Hao-ming.,Zhu, Min-zheng.,...&Yao, Jun.(2023).Plant-derived exosomal nanoparticles: potential therapeutic for inflammatory bowel disease.NANOSCALE ADVANCES,5(14).

Li, De-feng,et al."Plant-derived exosomal nanoparticles: potential therapeutic for inflammatory bowel disease".NANOSCALE ADVANCES 5.14(2023).