| 题名 | Organoids as Innovative Models for Bone and Joint Diseases |
| 作者 | |
| 通讯作者 | Zhang, Lingqiang; Lu, Aiping; Liang, Chao |
| 发表日期 | 2023-06-01
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| DOI | |
| 发表期刊 | |
| EISSN | 2073-4409
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| 卷号 | 12期号:12 |
| 摘要 | Bone is one of the key components of the musculoskeletal system. Bone and joint disease are the fourth most widespread disease, in addition to cardiovascular disease, cancer, and diabetes, which seriously affect people's quality of life. Bone organoids seem to be a great model by which to promote the research method, which further could improve the treatment of bone and joint disease in the future. Here, we introduce the various bone and joint diseases and their biology, and the conditions of organoid culture, comparing the in vitro models among 2D, 3D, and organoids. We summarize the differing potential methods for culturing bone-related organoids from pluripotent stem cells, adult stem cells, or progenitor cells, and discuss the current and promising bone disease organoids for drug screening and precision medicine. Lastly, we discuss the challenges and difficulties encountered in the application of bone organoids and look to the future in order to present potential methods via which bone organoids might advance organoid construction and application. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 第一
; 通讯
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| WOS研究方向 | Cell Biology
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| WOS类目 | Cell Biology
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| WOS记录号 | WOS:001014192300001
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：10
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/549204 |
| 专题 | 生命科学学院_生物系 生命科学学院 |
| 作者单位 | 1.Southern Univ Sci & Technol, Sch Life Sci, Dept Biol, Shenzhen 518055, Peoples R China 2.Hong Kong Baptist Univ, Inst Integrated Bioinfomedicine & Translat Sci IBT, Sch Chinese Med, Hong Kong, Peoples R China 3.Beijing Inst Life, Natl Ctr Prot Sci Beijing, State Key Lab Prote, Beijing 102206, Peoples R China 4.Shanghai Acad Tradit Chinese Med, Inst Arthrit Res Integrat Med, Shanghai 200052, Peoples R China 5.Guangdong Hong Kong Macau Joint Lab Chinese Med &, Hong Kong 510120, Guangdong, Peoples R China |
| 第一作者单位 | 生物系; 生命科学学院 |
| 通讯作者单位 | 生物系; 生命科学学院 |
| 第一作者的第一单位 | 生物系; 生命科学学院 |
| 推荐引用方式 GB/T 7714 |
Huang, Jie,Zhang, Lingqiang,Lu, Aiping,et al. Organoids as Innovative Models for Bone and Joint Diseases[J]. CELLS,2023,12(12).
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| APA |
Huang, Jie,Zhang, Lingqiang,Lu, Aiping,&Liang, Chao.(2023).Organoids as Innovative Models for Bone and Joint Diseases.CELLS,12(12).
|
| MLA |
Huang, Jie,et al."Organoids as Innovative Models for Bone and Joint Diseases".CELLS 12.12(2023).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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