| 题名 | Proline-conditioning and chemically-programmed ice nucleation protects spheroids during cryopreservation |
| 作者 | |
| 通讯作者 | Guo, Qiongyu; Gibson, Matthew I. |
| 发表日期 | 2023-07-01
|
| DOI | |
| 发表期刊 | |
| ISSN | 1359-7345
|
| EISSN | 1364-548X
|
| 卷号 | 59期号:59页码:9086-9089 |
| 摘要 | Spheroids mimic 3-D tissue niches better than standard cell cultures. Cryopreserving spheroids, however, remains challenging as conventional cryoprotectants do not mitigate all damage mechanisms. Here chemically-programmed extracellular ice nucleation is used to prevent supercooling, alongside proline pre-conditioning, which are found to synergystically improve post-thaw recovery of spheroids. This validates the need to identify compounds and materials to address both biochemical and biophysical damage pathways beyond standard cryoprotectants. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 重要成果 | NI论文
|
| 学校署名 | 通讯
|
| WOS研究方向 | Chemistry
|
| WOS类目 | Chemistry, Multidisciplinary
|
| WOS记录号 | WOS:001021682700001
|
| 出版者 | |
| EI入藏号 | 20233014427716
|
| EI主题词 | Biological materials preservation
; Nucleation
|
| EI分类号 | Biological Materials and Tissue Engineering:461.2
; Crystal Growth:933.1.2
|
| ESI学科分类 | CHEMISTRY
|
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：5
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/549273 |
| 专题 | 工学院_生物医学工程系 |
| 作者单位 | 1.Univ Warwick, Dept Chem, Coventry CV4 7AL, England 2.Univ Warwick, Warwick Med Sch, Div Biomed Sci, Coventry CV4 7AL, England 3.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen 518055, Guangdong, Peoples R China |
| 第一作者单位 | 生物医学工程系 |
| 通讯作者单位 | 生物医学工程系 |
| 推荐引用方式 GB/T 7714 |
Gao, Yanan,Bissoyi, Akalabya,Kinney, Nina L. H.,et al. Proline-conditioning and chemically-programmed ice nucleation protects spheroids during cryopreservation[J]. CHEMICAL COMMUNICATIONS,2023,59(59):9086-9089.
|
| APA |
Gao, Yanan,Bissoyi, Akalabya,Kinney, Nina L. H.,Whale, Thomas F.,Guo, Qiongyu,&Gibson, Matthew I..(2023).Proline-conditioning and chemically-programmed ice nucleation protects spheroids during cryopreservation.CHEMICAL COMMUNICATIONS,59(59),9086-9089.
|
| MLA |
Gao, Yanan,et al."Proline-conditioning and chemically-programmed ice nucleation protects spheroids during cryopreservation".CHEMICAL COMMUNICATIONS 59.59(2023):9086-9089.
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| 条目包含的文件 | 条目无相关文件。 | |||||
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