Chemoproteomics reveals Sofalcone inhibits the inflammatory response of Caco-2 cells by covalently targeting HMGB1

Yang, Tong1; Liu, Dandan2,3; Li, Yulei5; Zhang, Ying2,3; Zhu, Yinhua2,3; Zhang, Junzhe2,3; Wang, Chen2,3; Zhang, Shujie2,3; Wong, Yin Kwan4; Luo, Piao2,3; Guo, Qiuyan2,3; Xia, Fei2,3; Zhong, Tianyu1; Tang, Huan2,3; Wang, Jigang1,2,3,6,7

2023-05-01

10.1039/d3cc00577a

CHEMICAL COMMUNICATIONS   影响因子和分区

1359-7345

1364-548X

Sofalcone (Sof), a synthetic analog of sophoradin, is a type of natural phenol derived from the traditional medicinal herb Sophora subprostrata, with potent anti-inflammatory activity. However, the mechanisms of action of Sof for treating intestinal-associated inflammation are not well known. In this work, we identified high mobility group box 1 (HMGB1) as the key covalent target of Sof for the anti-inflammatory activity in the human colonic epithelial cells through quantitative chemoproteomics profiling.

SCI

英语

NI论文

通讯

National Key Research and Development Program of China["2020YFA0908000","2022YFC2303600"] ; Innovation Team and Talents Cultivation Program of the National Administration of Traditional Chinese Medicine[ZYYCXTD-C-202002] ; National Natural Science Foundation of China["32201177","82204672","82141001","82074098"] ; Fundamental Research Funds for the Central public welfare research institutes["ZZ16-ND-10-24","ZZ16-ND-10-25","ZZ15-ND-10","ZZ14-FL-002","CI2021A05101","CI2021A05104"] ; CACMS Innovation Fund["ZZ14-YQ-061","ZZ15-YQ-063"]

Chemistry

Chemistry, Multidisciplinary

WOS:001020543100001

ROYAL SOC CHEMISTRY

CHEMISTRY

Web of Science

1.Gannan Med Univ, Lab Med, Affiliated Hosp 1, Ganzhou 341000, Peoples R China
2.China Acad Chinese Med Sci, Artemisinin Res Ctr, Beijing 100700, Peoples R China
3.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China
4.Natl Univ Singapore, Dept Biol Sci, Singapore 117543, Singapore
5.Gannan Med Univ, Blood Transfus Dept, Affiliated Hosp 1, Ganzhou 341000, Peoples R China
6.Southern Univ Sci & Technol, Dept Nephrol, Shenzhen Key Lab Kidney Dis, Shenzhen 518020, Peoples R China
7.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen Clin Res Ctr Geriatr, Shenzhen 518020, Peoples R China

Yang, Tong,Liu, Dandan,Li, Yulei,et al. Chemoproteomics reveals Sofalcone inhibits the inflammatory response of Caco-2 cells by covalently targeting HMGB1[J]. CHEMICAL COMMUNICATIONS,2023,59(58).

Yang, Tong.,Liu, Dandan.,Li, Yulei.,Zhang, Ying.,Zhu, Yinhua.,...&Wang, Jigang.(2023).Chemoproteomics reveals Sofalcone inhibits the inflammatory response of Caco-2 cells by covalently targeting HMGB1.CHEMICAL COMMUNICATIONS,59(58).

Yang, Tong,et al."Chemoproteomics reveals Sofalcone inhibits the inflammatory response of Caco-2 cells by covalently targeting HMGB1".CHEMICAL COMMUNICATIONS 59.58(2023).