Tuning the Organ Tropism of Polymersome for Spleen-Selective Nanovaccine Delivery to Boost Cancer Immunotherapy

Gu, Wenxing1,2,3,4,5,6; An, Jingnan7; Li, Yaxi6; Yang, Yajie1; Wang, Shumin1; Shan, Hui1; Li, Shenhua1; Li, Hui1,2,3,4,5; Liu, Guoyong1; Li, Kai6; Yin, Yuxin1; Mu, Jing1; Chen, Xiaoyuan2,3,4,5

2023-06-01

10.1002/adma.202301686

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

The past few decades have witnessed explosive development in drug delivery systems. However, in vivo delivery suffers from non-specific distribution in non-targeted organs or tissues, which may cause undesired side effects and even genotoxicity. Here, a general strategy that enables tuning the tropism of polymersomes for liver- and spleen-selective delivery is reported. By using a library screening approach, spleen-targeted polymersome PH9-Aln-8020 and liver-targeted polymersome PA9-ZP3-5050 are identified accordingly. Meanwhile, the second near-infrared (NIR-II) fluorescence imaging allows for in vivo dynamic evaluation of their spatial and temporal accumulation in specific tissues. O ur findings indicate that both polymer composition and protein corona on the surface are essential to determine the in vivo fate of polymersomes and tendency for specific organs. Importantly, PH9-Aln-8020 is employed as a systemic nanocarrier to co-deliver the antigen and adjuvant, which remarkably boost splenic immune responses in acute myeloid leukemia, melanoma, and melanoma lung metastasis mouse models. This study may open a new frontier for polymersomes in organ-selective delivery and other biomedical applications.

immunotherapy nanovaccines organ selectivity polymersomes spleen

SCI ; EI

英语

NI论文

通讯

National Natural Science Foundation of China["32101074","82000157","U21A2097"] ; Basic Research Program of Shenzhen[JCYJ20220531093608019] ; Ministry of Science and Technology of China[2020YFA0908900] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; Department of Science and Technology of Guangdong Province[2019ZT08Y191] ; Shenzhen Science and Technology Program["KQTD20190929172743294","RCYH20221008092946108"] ; National University of Singapore[NUHSRO/2020/133/Startup/08] ; NUS School of Medicine Nanomedicine Translational Research Programme[NUHSRO/2021/034/TRP/09/Nanomedicine] ; National Medical Research Council (NMRC) Centre Grant Programme[CG21APR1005]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:001020026200001

WILEY-V C H VERLAG GMBH

20232714341784

Biocompatibility ; Controlled drug delivery ; Dermatology ; Diseases ; Fluorescence imaging ; Functional polymers ; Histology ; Infrared devices ; Medical applications ; Oncology ; Targeted drug delivery

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Imaging Techniques:746 ; Polymeric Materials:815.1

MATERIALS SCIENCE

Web of Science

1.Peking Univ, Shenzhen Hosp, Inst Precis Med, Shenzhen 518036, Peoples R China
2.Natl Univ Singapore, Coll Design & Engn, Yong Loo Lin Sch Med, Dept Diagnost Radiol, Singapore 119074, Singapore
3.Natl Univ Singapore, Coll Design & Engn, Yong Loo Lin Sch Med, Dept Surg, Singapore 119074, Singapore
4.Natl Univ Singapore, Coll Design & Engn, Yong Loo Lin Sch Med, Dept Chem & Biomol Engn, Singapore 119074, Singapore
5.Natl Univ Singapore, NUS Ctr Nanomed, Yong Loo Lin Sch Med, Nanomed Translat Res Program, Singapore 117597, Singapore
6.Southern Univ Sci & Technol, Dept Biomed Engn, Shenzhen Key Lab Smart Healthcare Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China
7.Soochow Univ, Affiliated Hosp 1, Inst Blood & Marrow Transplantat, Collaborat Innovat Ctr Hematol, Suzhou 215123, Peoples R China

Gu, Wenxing,An, Jingnan,Li, Yaxi,et al. Tuning the Organ Tropism of Polymersome for Spleen-Selective Nanovaccine Delivery to Boost Cancer Immunotherapy[J]. ADVANCED MATERIALS,2023,35(41).

Gu, Wenxing.,An, Jingnan.,Li, Yaxi.,Yang, Yajie.,Wang, Shumin.,...&Chen, Xiaoyuan.(2023).Tuning the Organ Tropism of Polymersome for Spleen-Selective Nanovaccine Delivery to Boost Cancer Immunotherapy.ADVANCED MATERIALS,35(41).

Gu, Wenxing,et al."Tuning the Organ Tropism of Polymersome for Spleen-Selective Nanovaccine Delivery to Boost Cancer Immunotherapy".ADVANCED MATERIALS 35.41(2023).