南方科技大学知识苑(SUSTech KC): Combined oral antibiotics and intrauterine perfusion can improve in vitro fertilization and embryo transfer pregnancy outcomes in patients with chronic endometritis and repeated embryo implantation failure

题名	Combined oral antibiotics and intrauterine perfusion can improve in vitro fertilization and embryo transfer pregnancy outcomes in patients with chronic endometritis and repeated embryo implantation failure
作者	Ma, Nana 1; Li, Jiaxu 1; Zhang, Junlei 2; Jin, Yufu 1; Wang, Jiawei 1; Qin, Weili 1; Hang, Fu 1; Qin, Aiping 1
通讯作者	Hang, Fu; Qin, Aiping
发表日期	2023-06-30
DOI	10.1186/s12905-023-02443-8
发表期刊	BMC WOMENS HEALTH 影响因子和分区
EISSN	1472-6874
卷号	23 期号:1
摘要	BackgroundThe aim of this retrospective study was to investigate whether oral antibiotics (doxycycline and metronidazole) combined with intrauterine perfusion (gentamicin and dexamethasone) are beneficial for patients with repeated implantation failure (RIF) and chronic endometritis (CE) to improve clinical pregnancy outcomes.MethodsPatients with RIF and CE were diagnosed using hysteroscopy and histology together. A total of 42 patients were enrolled in the study. All patients received oral antibiotics (doxycycline combined with metronidazole) and 22 patients underwent intrauterine perfusion (gentamicin combined with dexamethasone) immediately after the end of oral antibiotic therapy. Pregnancy outcomes were evaluated during the first in vitro fertilization (IVF) and embryo transfer (ET) cycle.ResultsFor the first D3 ET after treatment with oral antibiotics (doxycycline and metronidazole) combined with intrauterine perfusion (gentamicin and dexamethasone), higher embryo implantation rate (30.95% vs. 26.67%, P = 0.0308), clinical pregnancy rate (30% vs. 50%, P < 0.001), live birth rate (33.33% vs. 45.45%, P < 0.0001). No fetal malformations or ectopic pregnancies were observed.ConclusionWe report oral antibiotics (doxycycline and metronidazole) combined with intrauterine perfusion (gentamicin and dexamethasone) as a novel treatment for CE to improve the outcomes of successful pregnancy compared with those of oral antibiotics alone.
关键词	Oral antibiotics Intrauterine perfusion Repeated implantation failure Chronic endometritis Pregnancy outcomes
相关链接	[来源记录]
收录类别	SCI ; SSCI
语种	英语
学校署名	其他
WOS研究方向	Public, Environmental & Occupational Health ; Obstetrics & Gynecology
WOS类目	Public, Environmental & Occupational Health ; Obstetrics & Gynecology
WOS记录号	WOS:001020959000001
出版者	BMC
Scopus记录号	2-s2.0-85164037676
来源库	Web of Science
引用统计	被引频次[WOS]：3
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/549348
专题	南方科技大学医院
作者单位	1.Guangxi Med Univ, Affiliated Hosp 1, Ctr Reprod Med, Nanning, Peoples R China 2.Southern Univ Sci & Technol Hosp, Dept Sports Med, Shenzhen, Peoples R China
推荐引用方式 GB/T 7714	Ma, Nana,Li, Jiaxu,Zhang, Junlei,et al. Combined oral antibiotics and intrauterine perfusion can improve in vitro fertilization and embryo transfer pregnancy outcomes in patients with chronic endometritis and repeated embryo implantation failure[J]. BMC WOMENS HEALTH,2023,23(1).
APA	Ma, Nana.,Li, Jiaxu.,Zhang, Junlei.,Jin, Yufu.,Wang, Jiawei.,...&Qin, Aiping.(2023).Combined oral antibiotics and intrauterine perfusion can improve in vitro fertilization and embryo transfer pregnancy outcomes in patients with chronic endometritis and repeated embryo implantation failure.BMC WOMENS HEALTH,23(1).
MLA	Ma, Nana,et al."Combined oral antibiotics and intrauterine perfusion can improve in vitro fertilization and embryo transfer pregnancy outcomes in patients with chronic endometritis and repeated embryo implantation failure".BMC WOMENS HEALTH 23.1(2023).