Ultrasound Triggered Tumor Metabolism Suppressor Induces Tumor Starvation for Enhanced Sonodynamic Immunotherapy of Breast Cancer

Qiao, Kun1; Luo, Cheng2; Huang, Rong3,4; Xiang, Jingfeng5,6; Pan, You3,4; Zhang, Shiyuan1; Jiang, Cong1; Ding, Shuaijie7,8; Yang, Huawei3,4; Huang, Yuanxi1; Ning, Shipeng3,4

2023

10.2147/IJN.S413543

INTERNATIONAL JOURNAL OF NANOMEDICINE   影响因子和分区

1178-2013

Introduction: Sonodynamic therapy (SDT) as an emerging tumor treatment gained wide attention. However, tumor vascular destruction and oxygen depletion in SDT process may lead to further hypoxia. This may lead to enhanced glycolysis, lactate accumulation, and immunosuppression. Methods: A glycolysis inhibitor (3PO) loaded and PEG modified black phosphorus nanosheets (BO) is constructed for potent starvation therapy and efficient immune activation.Results: Under ultrasound irradiation, the BO can produce ROS to destroy tumors and tumor blood vessels and lead to further hypoxia and nutrients block. Then, the released 3PO inhibits tumor glycolysis and prevents the hypoxia-induced glycolysis and lactate accumulation. Both SDT and 3PO can cut off the source of lactic acid, as well as achieve antitumor starvation therapy through the blockade of the adenosine triphosphate (ATP) supply. In addition, the combination of starvation treatment and SDT further facilitates dendritic cells (DC) maturation, promotes antigen presentation by DCs, and eventually propagates the antitumor immunity and inhibition of abscopal tumor growth.Conclusion: This is the first time that combines SDT with inhibition of glycolysis, achieving admirable tumor treatment and decreasing adverse events caused by SDT process and that has caused good immune activation. Our system provides a new idea for the future design of anti-tumor nanomedicines.

sonodynamic therapy glycolysis inhibitor black phosphorus nanosheets starvation therapy immune activation

SCI

英语

其他

Guangxi Natural Science Foundation[2023GXNSFBA026137] ; Haiyan Foundation of Harbin Medical University Cancer Hospital[JJQN2022-01] ; China Postdoctoral Science Foundation[2022M710853] ; Beijing Cancer Prevention amp; Treatment Society[IZXUEYANZI2022-1004]

Science & Technology - Other Topics ; Pharmacology & Pharmacy

Nanoscience & Nanotechnology ; Pharmacology & Pharmacy

WOS:001024360700001

DOVE MEDICAL PRESS LTD

Web of Science

1.Harbin Med Univ, Dept Breast Surg, Canc Hosp, Harbin 150081, Peoples R China
2.Maternal & Child Hlth Hosp Guangxi Zhuang Autonomo, Dept Anesthesiol, Nanning 530000, Peoples R China
3.Guangxi Med Univ, Canc Hosp, Nanning 530000, Peoples R China
4.Treatment Res Guangxi Dept Educ, Key Lab Breast Canc Diag, Nanning 530000, Peoples R China
5.Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Guangdong Prov Key Lab Precis Med Gastrointestinal, Guangzhou 510515, Guangdong, Peoples R China
6.Southern Med Univ, Dept Gen Surg, Guangzhou 510515, Guangdong, Peoples R China
7.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Second Clin Med Coll,Dept Geriat, Shenzhen 518020, Guangdong, Peoples R China
8.Southern Univ Sci & Technol, Dept Gastrointestinal Surg, Shenzhen 518020, Guangdong, Peoples R China

Qiao, Kun,Luo, Cheng,Huang, Rong,et al. Ultrasound Triggered Tumor Metabolism Suppressor Induces Tumor Starvation for Enhanced Sonodynamic Immunotherapy of Breast Cancer[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2023,18.

Qiao, Kun.,Luo, Cheng.,Huang, Rong.,Xiang, Jingfeng.,Pan, You.,...&Ning, Shipeng.(2023).Ultrasound Triggered Tumor Metabolism Suppressor Induces Tumor Starvation for Enhanced Sonodynamic Immunotherapy of Breast Cancer.INTERNATIONAL JOURNAL OF NANOMEDICINE,18.

Qiao, Kun,et al."Ultrasound Triggered Tumor Metabolism Suppressor Induces Tumor Starvation for Enhanced Sonodynamic Immunotherapy of Breast Cancer".INTERNATIONAL JOURNAL OF NANOMEDICINE 18(2023).