南方科技大学知识苑(SUSTech KC): Asymmetric Dihydroxylation-Based Desymmetrization Enabled by Lone-Pair-p Interaction

题名	Asymmetric Dihydroxylation-Based Desymmetrization Enabled by Lone-Pair-p Interaction
作者	Zhen, Qianqian 1,2 ; Liu, Chao 1,2 ; Lv, Xinrou 1,2; Jin, Ming Yu1,2 ; Xu, Chen1,2
通讯作者	Xu, Chen
发表日期	2023-07-01
DOI	10.1021/acscatal.3c02488
发表期刊	ACS CATALYSIS 影响因子和分区
ISSN	2155-5435
卷号	13 期号:14页码:9745-9752
摘要	Lone-pair-p interactions, which form a stabilizing association between a lone pair of electrons and a p system, are widely recognized as supramolecular bonds. However, such noncovalent interactions rarely serve as a key stereocontrolling element in chemical reactions. Herein, we report a well-engineered lone-pair-p interaction-directed catalytic system for asymmetric dihydroxylation (AD)-based desymmetrization. The lone-pair-p interaction between the C9 carbonyl in mono-cinchona alkaloids and the electron-deficient phthalazine in the symmetric alkene substrates was exploited to realize a highly efficient AD-based desymmetrization, which was difficult to execute following the traditional Sharpless asymmetric dihydroxylation method.
关键词	lone-pair-& pi noncovalent & pi interaction desymmetrization asymmetric dihydroxylation poly hydroxylated product
相关链接	[来源记录]
收录类别	SCI ; EI
语种	英语
学校署名	第一 ; 通讯
资助项目	Shenzhen Nobel Prize Scientists Laboratory Project[C17783101] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] ; National Natural Science Foundation of China[22171128] ; Guangdong Basic and Applied Basic Research Foundation[2023B1515020019] ; Shenzhen Science and Technology Program[KQTD20180411143514543]
WOS研究方向	Chemistry
WOS类目	Chemistry, Physical
WOS记录号	WOS:001024253200001
出版者	AMER CHEMICAL SOC
EI入藏号	20233114456454
EI主题词	Association reactions ; Hydroxylation
EI分类号	Chemical Reactions:802.2
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/549361
专题	理学院_化学系深圳格拉布斯研究院
作者单位	1.Southern Univ Sci & Technol, Dept Chem, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China 2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China
第一作者单位	化学系; 深圳格拉布斯研究院
通讯作者单位	化学系; 深圳格拉布斯研究院
第一作者的第一单位	化学系
推荐引用方式 GB/T 7714	Zhen, Qianqian,Liu, Chao,Lv, Xinrou,et al. Asymmetric Dihydroxylation-Based Desymmetrization Enabled by Lone-Pair-p Interaction[J]. ACS CATALYSIS,2023,13(14):9745-9752.
APA	Zhen, Qianqian,Liu, Chao,Lv, Xinrou,Jin, Ming Yu,&Xu, Chen.(2023).Asymmetric Dihydroxylation-Based Desymmetrization Enabled by Lone-Pair-p Interaction.ACS CATALYSIS,13(14),9745-9752.
MLA	Zhen, Qianqian,et al."Asymmetric Dihydroxylation-Based Desymmetrization Enabled by Lone-Pair-p Interaction".ACS CATALYSIS 13.14(2023):9745-9752.