MACdb: A Curated Knowledgebase for Metabolic Associations across Human Cancers

Sun, Yanling1,2,4; Zheng, Xinchang1,2,4; Wang, Guoliang1,2,4,5; Wang, Yibo1,2,3,4,5; Chen, Xiaoning1,2,3,4,5; Sun, Jiani1,2,3,4,5,6; Xiong, Zhuang1,2,3,4,5; Zhang, Sisi1,2,3,4; Wang, Tianyi7; Fan, Zhuojing1,2,3,4; Bu, Congfan1,2,3,4; Bao, Yiming1,2,3,4,5,8; Zhao, Wenming1,2,3,4,5,7,8

2023-07-01

10.1158/1541-7786.MCR-22-0909

MOLECULAR CANCER RESEARCH   影响因子和分区

1541-7786

1557-3125

Cancer is one of the leading causes of human death. As metabo-lomics techniques become more and more widely used in cancer research, metabolites are increasingly recognized as crucial factors in both cancer diagnosis and treatment. In this study, we developed MACdb (https://ngdc.cncb.ac.cn/macdb), a curated knowledgebase to recruit the metabolic associations between metabolites and cancers. Unlike conventional data-driven resources, MACdb integrates can-cer-metabolic knowledge from extensive publications, providing high quality metabolite associations and tools to support multiple research purposes. In the current implementation, MACdb has integrated 40,710 cancer-metabolite associations, covering 267 traits from 17 categories of cancers with high incidence or mortality, based entirely on manual curation from 1,127 studies reported in 462 publications (screened from 5,153 research papers). MACdb offers intuitive browsing functions to explore associations at multi-dimensions (metabolite, trait, study, and publication), and constructs knowledge graph to provide overall landscape among cancer, trait, and metab-olite. Furthermore, NameToCid (map metabolite name to PubChem Cid) and Enrichment tools are developed to help users enrich the association of metabolites with various cancer types and traits. Implication: MACdb paves an informative and practical way to evaluate cancer-metabolite associations and has a great potential to help researchers identify key predictive metabolic markers in cancers.

SCI

英语

通讯

Strategic Priority Research Program of the Chinese Academy of Sciences[XDB38050300] ; Genomics Data Center Operation and Maintenance of Chinese Academy of Sciences[CAS-WX2022SDC-XK05]

Oncology ; Cell Biology

Oncology ; Cell Biology

WOS:001026267500001

AMER ASSOC CANCER RESEARCH

MOLECULAR BIOLOGY & GENETICS

Web of Science

1.Chinese Acad Sci, Beijing Inst Genom, Natl Genom Data Ctr, Beijing, Peoples R China
2.China Natl Ctr Bioinformat, Beijing, Peoples R China
3.Chinese Acad Sci, Beijing Inst Genom, CAS Key Lab Genome Sci & Informat, Beijing, Peoples R China
4.China Natl Ctr Bioin format, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Beijing, Peoples R China
6.Univ Chinese Acad Sci, Sino Danish Coll, Beijing, Peoples R China
7.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
8.Chinese Acad Sci, Beijing Inst Genom, Natl Genom Data Ctr, China Natl Ctr Bioinformat, Beijing 100101, Peoples R China

Sun, Yanling,Zheng, Xinchang,Wang, Guoliang,et al. MACdb: A Curated Knowledgebase for Metabolic Associations across Human Cancers[J]. MOLECULAR CANCER RESEARCH,2023,21(7).

Sun, Yanling.,Zheng, Xinchang.,Wang, Guoliang.,Wang, Yibo.,Chen, Xiaoning.,...&Zhao, Wenming.(2023).MACdb: A Curated Knowledgebase for Metabolic Associations across Human Cancers.MOLECULAR CANCER RESEARCH,21(7).

Sun, Yanling,et al."MACdb: A Curated Knowledgebase for Metabolic Associations across Human Cancers".MOLECULAR CANCER RESEARCH 21.7(2023).