A Low-Noise CMOS Front-End with 534 MΩ Transimpedance Gain for Single-Molecule Signal Acquisition

Chenyu Ma; Shanci Hu; Yuhang Hu; Tao Deng; Yuliang Han; Yi Li; Yuan Gao

10.1109/NEWCAS57931.2023.10198100

2023

IEEE Interregional NEWCAS Conference (NEWCAS)

2472-467X

979-8-3503-0025-3

2023 21st IEEE Interregional NEWCAS Conference (NEWCAS)

1-5

26-28 June 2023

Edinburgh, United Kingdom

We designed and characterized a low-noise RTIA (transimpedance amplifier) with $534 \mathrm{M}\Omega$ transimpedance gain fabricated in a $0.18- \mu \mathrm{m}$ CMOS process for pA signal acquisition, which lay the foundation for nanopore sequencing. A feedback resistance with $268 \mathrm{M}\Omega$ and source degeneration were firstly demonstrated to suppress the input referred noise. Next, dual-end output configuration was adapted for doubling the actual signal gain. Finally, we show an output buffer with the gain of 17 dB leading to $7 \times$ equivalent feedback capacitance can be utilized for boosting the bandwidth. Our experimental results confirm that this amplifier design can detect the interaction between DNA molecules and the nanopore sensor. The noise level of our system exhibits 5.5 pARMS (<1 kHz) and 14.1 pARMS (<5 kHz), which is in a reasonable agreement with our control tests on the “gold standard” Axo-patch 200B amplifier.

Transimpedance Amplifier (TIA) Single-molecule Signal Acquisition Transimpedance Gain Source Degeneration Output Buffer Nanopore Sensing Circuits

第一 ; 通讯

CPCI-S ; EI

WOS:001050763800070

20233414620320

CMOS integrated circuits ; Feedback ; Mergers and acquisitions ; Molecules ; Nanopores ; Signal processing ; Timing circuits

Amplifiers:713.1 ; Pulse Circuits:713.4 ; Semiconductor Devices and Integrated Circuits:714.2 ; Information Theory and Signal Processing:716.1 ; Control Systems:731.1 ; Nanotechnology:761 ; Atomic and Molecular Physics:931.3 ; Solid State Physics:933

IEEE

School of Microelectronics, Southern University of Science and Technology, Shenzhen, China

Chenyu Ma,Shanci Hu,Yuhang Hu,et al. A Low-Noise CMOS Front-End with 534 MΩ Transimpedance Gain for Single-Molecule Signal Acquisition[C],2023:1-5.