Hydrogel bioadhesives harnessing nanoscale phase separation for Achilles tendon repairing

Zhang, Jun1,2; Chen, Xingmei1; Lin, Jingseng1; Zhang, Pei1; Lei, Iek Man1; Tao, Yue1; Zhang, Jiajun1; Luo, Tian3; Liu, Ji1,4,5

2023-07-01

10.1007/s12274-023-5918-1

NANO RESEARCH   影响因子和分区

1998-0124

1998-0000

Repairing Achilles tendon has emerged as a long-standing challenge in the orthopaedic surgeries. Although suture is the gold standard for re-attaching and repairing the fractured Achilles tendons in clinical surgeries, it is still subjected to numerous adverse side-effects, including chronic inflammatory, tendon tissue re-rupture, scar formation, and post-surgical peritendinous adhesion. In this work, we develop a class of hydrogel bioadhesives with tailored nanoscale phase separation for Achilles tendon repairing. To address the existing limitations of sutures, our hydrogel bioadhesives encompass three core functionalities: (i) instant and tough adhesion to Achilles tendon tissues, (ii) extraordinary long-term adhesion robustness under wet and dynamic in vivo conditions, and (iii) anti-postsurgical peritendinous adhesion. Combining our hydrogel bioadhesives with sutures, such kind of integrated approach enables a conformable yet robust biointerface with the tendon tissues, and prevents the fibroblast migration and formation of connective tissues, thus facilitating the tendon repairing. The hydrogel bioadhesives reported here open up new opportunities for the repairing of fractured Achilles tendons in diverse and complicated clinical scenarios.

hydrogels phase separation bioadhesion robustness tendon repairing

SCI ; EI

英语

第一 ; 通讯

Natural Science Foundation of Guangdong Province["2022A1515010152","2021A1515110735"] ; Basic Research Program of Shenzhen["JCYJ20210324105211032","GJHZ20210705141809030"] ; Scientific Research Platforms and Projects of University of Guangdong Provincial Education Office[2022ZDZX3019] ; Science, Technology, and Innovation Commission of Shenzhen Municipality[ZDSYS20200811143601004]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied

WOS:001035727500001

TSINGHUA UNIV PRESS

20233014439290

Adhesion ; Cell culture ; Collagen ; Ductile fracture ; Histology ; Hydrogels ; Nanotechnology ; Repair ; Surgery ; Tendons

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Thermodynamics:641.1 ; Nanotechnology:761 ; Colloid Chemistry:801.3 ; Chemical Operations:802.3 ; Chemical Products Generally:804 ; Maintenance:913.5 ; Materials Science:951

Web of Science

1.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen 518055, Peoples R China
2.SKG Hlth Technol, Res & Innovat Ctr, Shenzhen 518000, Peoples R China
3.SAFE Shenzhen Med Technol Co Ltd, Shenzhen 518000, Peoples R China
4.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen Key Lab Biomimet Robot & Intelligent Syst, Shenzhen 518055, Peoples R China
5.Southern Univ Sci & Technol, Guangdong Prov Key Lab Human Augmentat & Rehabil R, Shenzhen 518055, Peoples R China

Zhang, Jun,Chen, Xingmei,Lin, Jingseng,et al. Hydrogel bioadhesives harnessing nanoscale phase separation for Achilles tendon repairing[J]. NANO RESEARCH,2023.

Zhang, Jun.,Chen, Xingmei.,Lin, Jingseng.,Zhang, Pei.,Lei, Iek Man.,...&Liu, Ji.(2023).Hydrogel bioadhesives harnessing nanoscale phase separation for Achilles tendon repairing.NANO RESEARCH.

Zhang, Jun,et al."Hydrogel bioadhesives harnessing nanoscale phase separation for Achilles tendon repairing".NANO RESEARCH (2023).