南方科技大学知识苑(SUSTech KC): Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)

题名	Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)
作者	Wang, Huifang1 ; Zhou, Runhua 2; Xu, Fushan 3; Yang, Kongjun 3; Zheng, Liuhai 1; Zhao, Pan1 ; Shi, Guangwei 2; Dai, Lingyun 1; Xu, Chengchao 1,4; Yu, Le 2; Li, Zhijie 1 ; Wang, Jianhong 5; Wang, Jigang 1,2,4
通讯作者	Yu, Le; Li, Zhijie; Wang, Jianhong; Wang, Jigang
发表日期	2023-07-21
DOI	10.1186/s40824-023-00385-8
发表期刊	BIOMATERIALS RESEARCH 影响因子和分区
ISSN	1226-4601
EISSN	2055-7124
卷号	27 期号:1
摘要	Targeted protein degradation (TPD) is an emerging therapeutic strategy with the potential to modulate disease-associated proteins that have previously been considered undruggable, by employing the host destruction machinery. The exploration and discovery of cellular degradation pathways, including but not limited to proteasomes and lysosome pathways as well as their degraders, is an area of active research. Since the concept of proteolysis-targeting chimeras (PROTACs) was introduced in 2001, the paradigm of TPD has been greatly expanded and moved from academia to industry for clinical translation, with small-molecule TPD being particularly represented. As an indispensable part of TPD, biological TPD (bioTPD) technologies including peptide-, fusion protein-, antibody-, nucleic acid-based bioTPD and others have also emerged and undergone significant advancement in recent years, demonstrating unique and promising activities beyond those of conventional small-molecule TPD. In this review, we provide an overview of recent advances in bioTPD technologies, summarize their compositional features and potential applications, and briefly discuss their drawbacks. Moreover, we present some strategies to improve the delivery efficacy of bioTPD, addressing their challenges in further clinical development.
关键词	Biological targeted protein degradation (bioTPD) Peptide Antibody Fusion protein Nucleic acid
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:001032147500001
出版者	SPRINGERNATURE
Scopus记录号	2-s2.0-85165397107
来源库	Web of Science
引用统计	被引频次[WOS]：5
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/553270
专题	南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1,Shenzhen Clin Res Ctr Resp, Shenzhen Peoples Hosp,Shenzhen Inst Resp Dis, Shenzhen 518020, Guangdong, Peoples R China 2.Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Peoples R China 3.Jinan Univ, Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, R China, Shenzhen 518020, Guangdong, Peoples R China 4.China Acad Chinese Med Sci, Inst Chinese Mat Med, Artemisinin Res Ctr, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing 100700, Peoples R China 5.Shenzhen Kangning Hosp, Shenzhen Mental Hlth Ctr, Shenzhen 518020, Guangdong, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Wang, Huifang,Zhou, Runhua,Xu, Fushan,et al. Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)[J]. BIOMATERIALS RESEARCH,2023,27(1).
APA	Wang, Huifang.,Zhou, Runhua.,Xu, Fushan.,Yang, Kongjun.,Zheng, Liuhai.,...&Wang, Jigang.(2023).Beyond canonical PROTAC: biological targeted protein degradation (bioTPD).BIOMATERIALS RESEARCH,27(1).
MLA	Wang, Huifang,et al."Beyond canonical PROTAC: biological targeted protein degradation (bioTPD)".BIOMATERIALS RESEARCH 27.1(2023).