An injectable hydrogel based on Bi2Se3 nanosheets and hyaluronic acid for chemo-photothermal synergistic therapy

Liu, Qingyun1; Yang, Li1; Wang, Liangliang2; Li, Zimu1; Yu, Yongkang1; Zheng, Yi3; Lian, Daizheng4; Li, Xianming4; Chen, Hongzhong1; Mei, Lin5; Zeng, Xiaowei1; Gao, Nansha1

2023-07-31

10.1016/j.ijbiomac.2023.125064

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES   影响因子和分区

0141-8130

1879-0003

To resolve poor accumulation caused by systemic administration, injectable and responsive hydrogels are the prospective drug delivery systems for localized tumor treatment, owning to negligible invasiveness and accurate administration. Herein, an injectable hydrogel, based on dopamine (DA) crosslinked hyaluronic acid and Bi2Se3 nanosheets (NSs) loading with doxorubicin (DOX) coated with polydopamine (Bi2Se3-DOX@PDA), was devel-oped for synergistic chem-photothermal cancer therapy. The ultrathin functional Bi2Se3-DOX@PDA NSs could be responsive to the weak acidic condition and photothermal effect under NIR laser irradiation, achieving controlled release of DOX. Moreover, nanocomposite hydrogel based on hyaluronic acid matrix could be precisely administrated through intratumoral injection since its injectability and self-healing capacity, remaining at injected sites for at least 12 days. Furthermore, the excellent therapeutics effect of Bi2Se3-DOX@PDA nano -composite hydrogel was demonstrated on 4 T1 xenograft tumor with outstanding injectability and negligible systemic side-effect. In short, the construction of Bi2Se3-DOX@PDA nanocomposite hydrogel paves a prospective path for local treatment of cancers.

Bi2Se3 Hyaluronic acid Polydopamine Injectable hydrogel Chemo-photothermal therapy

SCI

英语

其他

Natural Science Foundation of Guangdong Province[2022A1515110271] ; Science, Technology amp; Innovation Commission of Shenzhen Municipality["JCYJ20210324113411032","JCYJ20220530165407018","JCYJ20220818102810023"] ; Open Research Fund Program of the State Key Laboratory of Virology of China[2022KF004] ; Guangming District Economic Development Special Fund[2021R01120]

Biochemistry & Molecular Biology ; Chemistry ; Polymer Science

Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science

WOS:001035634200001

ELSEVIER

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Shenzhen Campus Sun Yat sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen 518107, Peoples R China
2.Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Shenzhen Campus, Shenzhen 518107, Peoples R China
3.Univ Chinese Acad Sci, Shenzhen Hosp, Cent Lab, Shenzhen 518106, Peoples R China
4.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Radiat Oncol,Clin Med Coll, Shenzhen 518020, Peoples R China
5.Chinese Acad Med Sci & Peking Union Med Coll, Inst Biomed Engn, Key Lab Biomat & Nanotechnol Canc Immunotherapy, Tianjin Key Lab Biomed Mat, Tianjin 300192, Peoples R China

Liu, Qingyun,Yang, Li,Wang, Liangliang,et al. An injectable hydrogel based on Bi2Se3 nanosheets and hyaluronic acid for chemo-photothermal synergistic therapy[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2023,244.

Liu, Qingyun.,Yang, Li.,Wang, Liangliang.,Li, Zimu.,Yu, Yongkang.,...&Gao, Nansha.(2023).An injectable hydrogel based on Bi2Se3 nanosheets and hyaluronic acid for chemo-photothermal synergistic therapy.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,244.

Liu, Qingyun,et al."An injectable hydrogel based on Bi2Se3 nanosheets and hyaluronic acid for chemo-photothermal synergistic therapy".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 244(2023).