南方科技大学知识苑(SUSTech KC): Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure

题名	Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure
作者	Wang, Hai-Peng 1; Zhang, Na 2; Liu, Yu-Jie 3; Xia, Tian-Long 4; Chen, Guo-Chong 3; Yang, Jing 3,5; Li, Fu-Rong6,7,8
通讯作者	Yang, Jing; Li, Fu-Rong
发表日期	2023-07-01
DOI	10.1016/j.jlr.2023.100398
发表期刊	JOURNAL OF LIPID RESEARCH 影响因子和分区
ISSN	0022-2275
EISSN	1539-7262
卷号	64 期号:7
摘要	Lipoprotein(a) (Lp(a)) is a largely genetically determined biomarker for cardiovascular disease (CVD), while its potential interplay with family history (FHx) of CVD, a measure of both genetic and environmental exposures, remains unclear. We examined the associations of Lp(a) in terms of circulating concentration or polygenetic risk score (PRS), and FHx of CVD with risk of incident heart failure (HF). Included were 299,158 adults from the UK Biobank without known HF and CVD at baseline. Hazards ratios (HRs) and 95% Cls were estimated by Cox regression models adjusted for traditional risk factors defined by the Atherosclerosis Risk in Communities study HF risk score. During the 11.8-year follow-up, 5,502 incidents of HF occurred. Higher levels of circulating Lp(a), Lp(a) PRS, and positive FHx of CVD were associated with higher risks of HF. Compared with individuals who had lower circulating Lp(a) and no FHx, HRs (95% CIs) of HF were 1.36 (1.25, 1.49), 1.31 (1.19, 1.43), and 1.42 (1.22, 1.67) for those with higher Lp(a) and a positive history of CVD for all family members, parents, and siblings, respectively; similar results were observed by using Lp(a) PRS. The risk estimates for HF associated with elevated Lp(a) and positive FHx were attenuated after excluding those with incident myocardial infarction (MI) during follow-up. Lp(a) and FHx of CVD be partly mediated by myocardial infarction.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Chinese Postdoctoral Science Foundation[2022M721463]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:001033672900001
出版者	ELSEVIER
ESI学科分类	BIOLOGY & BIOCHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：0
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/553282
专题	南方科技大学医学院_公共卫生及应急管理学院
作者单位	1.Soochow Univ, Dept Cardiol, Affiliated Hosp 1, Suzhou, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Publ Hlth, Sch Med, Shanghai, Peoples R China 3.Soochow Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Suzhou Med Coll, Suzhou, Peoples R China 4.Shenzhen Ctr Dis Control & Prevent, Div Publ Hlth Emergency, Shenzhen, Guangdong, Peoples R China 5.Soochow Univ, Dept Clin Nutr, Affiliated Hosp 1, Suzhou, Peoples R China 6.Southern Univ Sci & Technol, Shenzhen Key Lab Cardiovasc Hlth & Precis Med, Shenzhen, Peoples R China 7.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China 8.Southern Med Univ, Sch Publ Hlth, Dept Epidemiol, Guangzhou, Peoples R China
通讯作者单位	南方科技大学; 公共卫生及应急管理学院
推荐引用方式 GB/T 7714	Wang, Hai-Peng,Zhang, Na,Liu, Yu-Jie,et al. Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure[J]. JOURNAL OF LIPID RESEARCH,2023,64(7).
APA	Wang, Hai-Peng.,Zhang, Na.,Liu, Yu-Jie.,Xia, Tian-Long.,Chen, Guo-Chong.,...&Li, Fu-Rong.(2023).Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure.JOURNAL OF LIPID RESEARCH,64(7).
MLA	Wang, Hai-Peng,et al."Lipoprotein(a), family history of cardiovascular disease, and incidence of heart failure".JOURNAL OF LIPID RESEARCH 64.7(2023).