Abnormal Decrease of Macrophage ALKBH5 Expression Causes Abnormal Polarization and Inhibits Osteoblast Differentiation

Weng, Junquan1,2,3; Fan, Haidong1,2,3; Liu, Huijuan1,2,3; Tang, Su1,2,3; Zheng, Yuyan1,2,3

2023-07-19

10.1155/2023/9974098

STEM CELLS INTERNATIONAL   影响因子和分区

1687-966X

1687-9678

Peri-implant tissue inflammation is an inflammatory injury that occurs in the soft and hard tissues surrounding the implant and is the main cause of short- or long-term failure of implant prosthetic restorations, which is compounded by bone loss and bone destruction in the alveolar bone of diabetes patients with peri-implantitis. However, the mechanisms underlying the persistence of diabetic peri-implantitis, as well as the essential connections and key molecules that regulate its start and progression, remain unknown. In this study, we discovered that M1 macrophage polarization was abnormally enhanced in diabetic peri-implantitis and influenced the osteogenic differentiation of mesenchymal stem cells. RNA sequencing revealed that ALKBH5 expression was abnormally reduced in diabetic peri-implantitis. Further mechanism study showed that ALKBH5 and its mediated m(6)A can influence osteogenic differentiation, which in turn influences the persistence of diabetic peri-implantitis. Our findings present a new mechanism for the suppression of osteoblast development in diabetic peri-implantitis and a new treatment strategy to promote anabolism by inhibiting ALKBH5.

SCI

英语

通讯

National Natural Science Foundation of China[81900972] ; Shenzhen Science and Technology Project[JCYJ20210324114200001]

Cell Biology

Cell & Tissue Engineering

WOS:001036060500001

HINDAWI LTD

Web of Science

1.Shenzhen Peoples Hosp, Dept Stomatol, Shenzhen 518020, Guangdong, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China

Weng, Junquan,Fan, Haidong,Liu, Huijuan,et al. Abnormal Decrease of Macrophage ALKBH5 Expression Causes Abnormal Polarization and Inhibits Osteoblast Differentiation[J]. STEM CELLS INTERNATIONAL,2023,2023.

Weng, Junquan,Fan, Haidong,Liu, Huijuan,Tang, Su,&Zheng, Yuyan.(2023).Abnormal Decrease of Macrophage ALKBH5 Expression Causes Abnormal Polarization and Inhibits Osteoblast Differentiation.STEM CELLS INTERNATIONAL,2023.

Weng, Junquan,et al."Abnormal Decrease of Macrophage ALKBH5 Expression Causes Abnormal Polarization and Inhibits Osteoblast Differentiation".STEM CELLS INTERNATIONAL 2023(2023).