Ligand-Modified Gold Nanoparticles as Mitochondrial Modulators: Regulation of Intestinal Barrier and Therapy for Constipation

Hao, Wenshuai1,2; Cha, Ruitao2; Wang, Mingzheng2; Li, Juanjuan2; Guo, Hongbo2; Du, Ran3; Zhou, Fengshan1; Jiang, Xingyu4

2023-07-01

10.1021/acsnano.3c01656

ACS NANO   影响因子和分区

1936-0851

1936-086X

Intestinal metabolism-related diseases,such as constipation, inflammatorybowel disease, irritable bowel syndrome, and colorectal cancer, couldbe associated with the dysfunction of intestinal mitochondria. Themitochondria of intestinal epithelial cells are of great significancefor promoting intestinal motility and maintaining intestinal metabolism.It is necessary for the prophylaxis and therapy of intestinal metabolism-relateddiseases to improve mitochondrial function. We investigated the effectof 4,6-diamino-2-pyrimidinethiol-modified gold nanoparticles (D-AuNPs) on intestinal mitochondria and studied the regulatory role ofD-Au NPs on mitochondria metabolism-related disease. D-Au NPs improvedthe antioxidation capability of mitochondria, regulated the mitochondrialmetabolism, and maintained intestinal cellular homeostasis via theactivation of AMPK and regulation of PGC-1 alpha with its ownstreamsignaling (UCP2 and DRP1), enhancing the intestinal mechanical barrier.D-Au NPs improved the intestinal mitochondrial function to intervenein the emergence of constipation, which could help develop drugs totreat and prevent mitochondrial metabolism-related diseases. Our findingsprovided an in-depth understanding of the mitochondrial effects ofAu NPs for improving human intestinal barriers.

gold nanoparticles 4,6-diamino-2-pyrimidinethiol ligand modification mitochondria intestinalmechanical barrier constipation

SCI ; EI

英语

NI论文

通讯

National Natural Science Foundation of China["32171397","21875050","32071390","81730051"] ; National Key Ramp;D Program of China[2018YFA0902600] ; Natural Science Foundation of Shenzhen[JCYJ20190814163201896] ; Shenzhen Science and Technology Program[KQTD20190929172743294] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003]

Chemistry ; Science & Technology - Other Topics ; Materials Science

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:001029690300001

AMER CHEMICAL SOC

20233214501268

Disease control ; Diseases ; Drug delivery ; Fiber optic sensors ; Gold compounds ; Ligands ; Metal nanoparticles ; Mitochondria

Biological Materials and Tissue Engineering:461.2 ; Fiber Optics:741.1.2 ; Nanotechnology:761 ; Physical Chemistry:801.4

Web of Science

1.China Univ Geosci Beijing, Sch Mat Sci & Technol, Beijing Key Lab Mat Utilizat Nonmet Minerals & Sol, Natl Lab Mineral Mat, Beijing 100083, Peoples R China
2.Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, Lab Theoret & Computat Nanosci, Beijing 100190, Peoples R China
3.Chinese Acad Agr Sci, Agr Genom Inst Shenzhen, Minist Agr & Rural Affairs, Genome Anal Lab,Shenzhen Branch,Guangdong Lab Ling, Shenzhen 518124, Peoples R China
4.Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen Key Lab Smart Healthcare Engn, Shenzhen 518055, Guangdong, Peoples R China

Hao, Wenshuai,Cha, Ruitao,Wang, Mingzheng,et al. Ligand-Modified Gold Nanoparticles as Mitochondrial Modulators: Regulation of Intestinal Barrier and Therapy for Constipation[J]. ACS NANO,2023,17(14):13377-13392.

Hao, Wenshuai.,Cha, Ruitao.,Wang, Mingzheng.,Li, Juanjuan.,Guo, Hongbo.,...&Jiang, Xingyu.(2023).Ligand-Modified Gold Nanoparticles as Mitochondrial Modulators: Regulation of Intestinal Barrier and Therapy for Constipation.ACS NANO,17(14),13377-13392.

Hao, Wenshuai,et al."Ligand-Modified Gold Nanoparticles as Mitochondrial Modulators: Regulation of Intestinal Barrier and Therapy for Constipation".ACS NANO 17.14(2023):13377-13392.