Small-molecule amines: a big role in the regulation of bone homeostasis

Zhang, Qian1,2; Yang, Jirong1,2; Hu, Nan3,4; Liu, Juan1; Yu, Huan5; Pan, Haobo1,2,6; Chen, Di5,7; Ruan, Changshun1,2

2023-07-24

10.1038/s41413-023-00262-z

BONE RESEARCH   影响因子和分区

2095-4700

2095-6231

Numerous small-molecule amines (SMAs) play critical roles in maintaining bone homeostasis and promoting bone regeneration regardless of whether they are applied as drugs or biomaterials. On the one hand, SMAs promote bone formation or inhibit bone resorption through the regulation of key molecular signaling pathways in osteoblasts/osteoclasts; on the other hand, owing to their alkaline properties as well as their antioxidant and anti-inflammatory features, most SMAs create a favorable microenvironment for bone homeostasis. However, due to a lack of information on their structure/bioactivity and underlying mechanisms of action, certain SMAs cannot be developed into drugs or biomaterials for bone disease treatment. In this review, we thoroughly summarize the current understanding of SMA effects on bone homeostasis, including descriptions of their classifications, biochemical features, recent research advances in bone biology and related regulatory mechanisms in bone regeneration. In addition, we discuss the challenges and prospects of SMA translational research.

SCI

英语

其他

National Natural Science Foundation of China["32122046","32000959","82030067","82161160342"] ; National Key Ramp;D Program[2018YFA0703100] ; Youth Innovation Promotion Association of CAS[2019350] ; Guangdong Natural Science Foundation[2020A1515111190] ; Shenzhen Fundamental Research Foundation["JCYJ20190812162809131","JCYJ20200109114006014","JCYJ20210324113001005","JCYJ20210324115814040","JSGGKQTD20210831174330015"] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties[SZGSP001]

Cell Biology

Cell & Tissue Engineering

WOS:001031668900001

SPRINGERNATURE

Web of Science

1.Chinese Acad Sci, Inst Biomed & Biotechnol, Shenzhen Inst Adv Technol, Res Ctr Human Tissue & Organs Degenerat, Shenzhen 518055, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Jinan Univ, Shenzhen Peoples Hosp, Dept Nephrol, Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
5.Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Comp Aided Drug Discovery, Shenzhen 518055, Peoples R China
6.Shenzhen Healthemes Biotechnol Co Ltd, Shenzhen 518102, Peoples R China
7.Chinese Acad Sci, Shenzhen Inst Adv Technol, Fac Pharmaceut Sci, Shenzhen 518055, Peoples R China

Zhang, Qian,Yang, Jirong,Hu, Nan,et al. Small-molecule amines: a big role in the regulation of bone homeostasis[J]. BONE RESEARCH,2023,11(1).

Zhang, Qian.,Yang, Jirong.,Hu, Nan.,Liu, Juan.,Yu, Huan.,...&Ruan, Changshun.(2023).Small-molecule amines: a big role in the regulation of bone homeostasis.BONE RESEARCH,11(1).

Zhang, Qian,et al."Small-molecule amines: a big role in the regulation of bone homeostasis".BONE RESEARCH 11.1(2023).