Early onset, development and histological features of gastric signet-ring cell carcinoma

Wang, Yangkun1; Li, Yingying2; Wang, Bin3; Ran, Dongmei4; Zhu, Chaoya5; Li, Ping6; Jiang, Bo7; Wang, Sunan2

2023-07-06

10.3389/fonc.2023.1166549

FRONTIERS IN ONCOLOGY   影响因子和分区

2234-943X

ObjectiveTo explore the early onset, development and histological features of gastric signet-ring cell carcinoma (SRCC). MethodsThree hundred and sixty-two patients with differentiated adenocarcinoma with signet-ring cells were enrolled. Histomorphological and immunohistochemical features and patterns of the specimens were observed in detail. ResultsInfection of the gastric mucosa, especially by Helicobacter pylori, can cause massive cell proliferation and transformation in the deep gastric foveola, the isthmus of the gastric gland, and the proliferative zone of the upper neck of the gland. Signet-ring-like heterocysts monoclonally proliferated after the redifferentiation and reproliferation, extending horizontally along the gastric foveola. Gastric foveolar-type SRCC grew infiltratively into the lamina propria of the mucosa and the submucosa, signet-ring cells could differentiate into undifferentiated adenocarcinoma with signet-ring cell differentiation, mucinous adenocarcinoma with signet-ring cell differentiation, gastric adenocarcinoma with signet-ring cell differentiation, and fundus gland adenocarcinoma with signet-ring cell differentiation. ConclusionEarly SRCC developed from the proliferative zones of the fundus of the gastric foveola and the neck of the gastric gland, growing horizontally along the gastric foveola. It developed into gastric adenocarcinoma with signet-ring cell differentiation after reproliferation and retransformation in the mucosa.

gastric foveolar epithelial type histopathology immunohistochemistry signet-ring cell carcinoma signet-ring cell differentiation signet-ring-like heterocysts

SCI

英语

其他

Key scientific and technological research projects in Henan Province[132102310008]

Oncology

Oncology

WOS:001032516100001

FRONTIERS MEDIA SA

Web of Science

1.Shenzhen Longgang Dist Fourth Peoples Hosp, Dept Pathol, Shenzhen, Peoples R China
2.Shenzhen Polytech, Shenzhen, Peoples R China
3.Shanghai Jiahui Int Hosp, Canc Ctr, Dept Radiat Therapy, Shanghai, Peoples R China
4.Southern Univ Sci & Technol Hosp, Dept Pathol, Shenzhen, Peoples R China
5.Zhengzhou Univ, Affiliated Hosp 3, Dept Pathol, Shenzhen, Peoples R China
6.Peking Univ, Shenzhen Hosp, Dept Pathol, Shenzhen, Peoples R China
7.990 Hosp Peoples Liberat Army PLA Joint Logist Sup, Dept Pathol, Zhumadian, Peoples R China

Wang, Yangkun,Li, Yingying,Wang, Bin,et al. Early onset, development and histological features of gastric signet-ring cell carcinoma[J]. FRONTIERS IN ONCOLOGY,2023,13.

Wang, Yangkun.,Li, Yingying.,Wang, Bin.,Ran, Dongmei.,Zhu, Chaoya.,...&Wang, Sunan.(2023).Early onset, development and histological features of gastric signet-ring cell carcinoma.FRONTIERS IN ONCOLOGY,13.

Wang, Yangkun,et al."Early onset, development and histological features of gastric signet-ring cell carcinoma".FRONTIERS IN ONCOLOGY 13(2023).