南方科技大学知识苑(SUSTech KC): AIEgen-based nanotherapeutic strategy for enhanced FLASH irradiation to prevent tumour recurrence and avoid severe side effects

题名	AIEgen-based nanotherapeutic strategy for enhanced FLASH irradiation to prevent tumour recurrence and avoid severe side effects
作者	Lyu, Meng 1,2,8; Zhang, Tianfu 9; Li, Yang 1,2,7,8 ; Xiang, Jingfeng 4,5; Zhu, Daoming 4,5; Xia, Ligang 1,2,8; Guo, Bin 7; Xu, Youhua 7; Yu, Haijun 3; Tang, Benzhong 6
通讯作者	Xu, Youhua; Yu, Haijun; Tang, Benzhong
发表日期	2023-10-01
DOI	10.1016/j.cej.2023.145179
发表期刊	CHEMICAL ENGINEERING JOURNAL 影响因子和分区
ISSN	1385-8947
EISSN	1873-3212
卷号	473
摘要	Compared with conventional radiotherapy, ultrahigh dose-rate (FLASH) radiotherapy spares normal tissues through oxygen exhaustion. However, residual cancer stem cells (CSCs) may generate tumour cells, causing tumour recurrence, which represents a critical problem after radiotherapy. Here we developed platelet cell membrane-camouflaged hollow TaOx nanospheres encapsulated with aggregation-induced emission luminogens (AIEgen) (named TPT). With characteristics derived from platelets, TPT nanoparticles (NPs) specifically target tumour regions and enhance FLASH radiotherapy via promoting the photoelectric effect by high Z-element tantalum and elevating reactive oxygen species levels through AIEgen-mediated photodynamic therapy (PDT). Under FLASH radiotherapy, TPT NPs exhibited a remarkable CSC killing effect, significantly inhibiting tumour recurrence. More important, compared with conventional radiotherapy, TPT NPs-promoted FLASH radiotherapy to efficiently eliminate tumours while reducing reoccurrence and severity of complications affecting normal tissues. This strategy provides a novel design to suppress tumour recurrence as well as to avoid adverse side effects.
关键词	FLASH Radiosensitization Photodynamic therapy Tumour recurrence AIEgen
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一
资助项目	null[AUP-220516-LM-0333-01]
WOS研究方向	Engineering
WOS类目	Engineering, Environmental ; Engineering, Chemical
WOS记录号	WOS:001054625800001
出版者	ELSEVIER SCIENCE SA
ESI学科分类	ENGINEERING
来源库	Web of Science
引用统计	被引频次[WOS]：11
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/553383
专题	南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Gastrointes, Shenzhen, Guangdong, Peoples R China 2.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,,Dept Geriatr, Shenzhen 518020, Guangdong, Peoples R China 3.Wuhan Univ, Zhongnan Hosp, Hubei Prov Canc Clin Study Ctr, Dept Radiat & Med Oncol,Hubei Key Lab Tumor Biol B, Wuhan 430071, Peoples R China 4.Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Dept Gen Surg, Guangzhou 510515, Guangdong, Peoples R China 5.Southern Med Univ, Nanfang Hosp, Sch Clin Med 1, Guangdong Prov Key Lab Precis Med Gastrointestinal, Guangzhou 510515, Guangdong, Peoples R China 6.Chinese Univ Hong Kong, Shenzhen Inst Mol Aggregate Sci & Engn, Sch Sci & Engn, 2001 Longxiang Blvd, Shenzhen 518172, Guangdong, Peoples R China 7.Macau Univ Sci & Technol, Fac Chinese Med, State Key Lab Qual Res Chinese Med, Taipa, Macao, Peoples R China 8.Shenzhen Peoples Hosp, Dept Gen Surg, Shenzhen 518020, Guangdong, Peoples R China 9.Guangzhou Med Univ, Sch Biomed Engn, Guangzhou, Peoples R China
第一作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Lyu, Meng,Zhang, Tianfu,Li, Yang,et al. AIEgen-based nanotherapeutic strategy for enhanced FLASH irradiation to prevent tumour recurrence and avoid severe side effects[J]. CHEMICAL ENGINEERING JOURNAL,2023,473.
APA	Lyu, Meng.,Zhang, Tianfu.,Li, Yang.,Xiang, Jingfeng.,Zhu, Daoming.,...&Tang, Benzhong.(2023).AIEgen-based nanotherapeutic strategy for enhanced FLASH irradiation to prevent tumour recurrence and avoid severe side effects.CHEMICAL ENGINEERING JOURNAL,473.
MLA	Lyu, Meng,et al."AIEgen-based nanotherapeutic strategy for enhanced FLASH irradiation to prevent tumour recurrence and avoid severe side effects".CHEMICAL ENGINEERING JOURNAL 473(2023).