Immune regulation in gastric adenocarcinoma is linked with therapeutic efficacy and improved recovery

Xu, Zhenglei1; Lin, Ximin2; Zeng, Haotian2; Ma, Xiaoxin1; Nabi, Ghulam3; Abidin, Zain Ul4; Wang, Luolin1; Wang, Lisheng1

2023-08-11

10.3389/fgene.2023.1238248

FRONTIERS IN GENETICS   影响因子和分区

1664-8021

Adenocarcinomas are one of the most common histological types of gastric cancer. It has been ranked fifth among common cancers and is the third among death causing cancers worldwide. The high mortality rate among patients with gastric cancer is because of its silent evolution, genetic heterogeneity, high resistance to chemotherapy as well as unavailability of highly effective therapeutic strategy. Until now a number of several treatment strategies have been developed and are being practiced such as surgery, chemotherapy, radio therapy, and immunotherapy, however, further developments are required to improve the treatment responses and reduce the side effects. Therefore, novel personal therapeutic strategies based on immunological responses should be developed by targeting different check points and key immune players. Targeting macrophages and related molecular elements can be useful to achieve these goals. In this minireview, we discuss the available treatment options, molecular underpinnings and immunological regulations associated with gastric adenocarcinoma. We further describe the possible check points and immunological targets that can be used to develop novel therapeutic options.

adenocarcinomas diagnosis gastric cancer biomarker therapy

SCI

英语

第一 ; 通讯

Genetics & Heredity

Genetics & Heredity

WOS:001054333400001

FRONTIERS MEDIA SA

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Gastroenterol,Clin Med Coll, Shenzhen, Guangdong, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
3.Polish Acad Sci, Inst Nat Conservat, Krakow, Poland
4.Kabir Med Coll, Dept Intens Care Unit, Peshawar, Pakistan

Xu, Zhenglei,Lin, Ximin,Zeng, Haotian,et al. Immune regulation in gastric adenocarcinoma is linked with therapeutic efficacy and improved recovery[J]. FRONTIERS IN GENETICS,2023,14.

Xu, Zhenglei.,Lin, Ximin.,Zeng, Haotian.,Ma, Xiaoxin.,Nabi, Ghulam.,...&Wang, Lisheng.(2023).Immune regulation in gastric adenocarcinoma is linked with therapeutic efficacy and improved recovery.FRONTIERS IN GENETICS,14.

Xu, Zhenglei,et al."Immune regulation in gastric adenocarcinoma is linked with therapeutic efficacy and improved recovery".FRONTIERS IN GENETICS 14(2023).