Self-cascade catalytic single-atom nanozyme for enhanced breast cancer low-dose radiotherapy

Qi, Pengyuan2; Luo, Cheng3; Pan, You1; Ding, Shuaijie4,5; Li, Xiang7,8,9; Qiao, Kun6; Ning, Shipeng1

2023-07-01

10.1016/j.colsurfb.2023.113347

COLLOIDS AND SURFACES B-BIOINTERFACES   影响因子和分区

0927-7765

1873-4367

Radiotherapy (RT) efficacy can be promoted with the help of nanoenzyme that can "re-programing" the tumour's micro-environment by changing the expression level of special bio-molecules. However, problems such as low reaction efficiency, limited endogenous H2O2, and/or unsatisfactory results of a single catalysis mode in treatment limit the application in the RT field. Herein, a novel Au nanoparticles (AuNPs) decorated iron SAE (FeSAE@Au) was formulated for self-cascade catalytic RT. In this dual-nanozyme system, embedded AuNPs can sever as GOx and endow FeSAE@Au with self-H2O2 supplying ability, which can elevate the H2O2 level in tumors by catalyzing cellular glucose in situ, further improving the catalytic performance of FeSAE with peroxidase-like activity. The self-cascade catalytic reaction can significantly increase cellular hydroxyl radicals (& BULL;OH) level, further promoting RT's effect. Furthermore, in vivo findings demonstrated that FeSAE can effectively limit tumor growth while causing low damage in important organs. According to our understanding, FeSAE@Au is the first description of a hybrid SAE-based nanomaterial employed in cascade catalytic RT. The research yields new and interesting insights for developing various SAE systems for anticancer therapy.

Single-atom nanozyme Glucose oxidase Low-dose radiotherapy Cascade catalysis

SCI

英语

其他

null[JJQN2022-01]

Biophysics ; Chemistry ; Materials Science

Biophysics ; Chemistry, Physical ; Materials Science, Biomaterials

WOS:001052921400001

ELSEVIER

BIOLOGY & BIOCHEMISTRY

Web of Science

1.Guangxi Med Univ, Canc Hosp, Nanning 530000, Peoples R China
2.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Canc Ctr, Wuhan 430022, Peoples R China
3.Maternal & Child Hlth Hosp Guangxi Zhuang Autonomo, Dept Anesthesiol, Nanning 530000, Peoples R China
4.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Gastrointestinal Surg,Clin, Shenzhen 518020, Peoples R China
5.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Geriat,Clin Med Coll 2, Shenzhen 518020, Peoples R China
6.Harbin Med Univ, Canc Hosp, Dept Breast Surg, Harbin 150081, Peoples R China
7.Xuzhou Med Univ, Dept Cent Lab, Affiliated Huaian Hosp, Huaian 223001, Peoples R China
8.Xuzhou Med Univ, Affiliated Huaian Hosp, Precis Med Ctr, Dept Nephrol, Huaian 223001, Peoples R China
9.Huaian Second Peoples Hosp, Huaian 223001, Peoples R China

Qi, Pengyuan,Luo, Cheng,Pan, You,et al. Self-cascade catalytic single-atom nanozyme for enhanced breast cancer low-dose radiotherapy[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2023,227.

Qi, Pengyuan.,Luo, Cheng.,Pan, You.,Ding, Shuaijie.,Li, Xiang.,...&Ning, Shipeng.(2023).Self-cascade catalytic single-atom nanozyme for enhanced breast cancer low-dose radiotherapy.COLLOIDS AND SURFACES B-BIOINTERFACES,227.

Qi, Pengyuan,et al."Self-cascade catalytic single-atom nanozyme for enhanced breast cancer low-dose radiotherapy".COLLOIDS AND SURFACES B-BIOINTERFACES 227(2023).