A tumor cell exosome-mimicking multifunctional nanozyme for targeted breast cancer radiotherapy

Chen, Gaili1; Jiang, Dazhen1; Ding, Shuaijie2,3; Huang, Chunyu4; Zhu, Daoming4; Jiang, Huangang1

2023-09-01

10.1039/d3nr03065

NANOSCALE   影响因子和分区

2040-3364

2040-3372

["Radiotherapy (RT) has been extensively used for the treatment of breast cancer. However, the efficacy of RT is reduced by the high content of reducing species within cells (such as glutathione (GSH)). In addition, high-dose radiotherapy is often accompanied by serious side effects. In an attempt to resolve these issues, a tumor cell exosome-mimicking multifunctional nanozyme system (CuPy-Au@EM) was developed as a radiosensitizer, which consists of an internal AuNP-embedded CuPy nanozyme core and an external tumor cell exosome membrane. The exosome membrane protein on the surface of CuPy-Au@EM leads to the accurate localization of nano-materials in the tumor site; simultaneously, the level of H2O2 will be enhanced because of the GOx-like activity of AuNPs. Then CuPy-Au@EM would continue to trigger a rapid decline in cellular GSH content and the production of a large number of hydroxyl radicals (OH) through its glutathione peroxidase (GPx) and peroxidase (POD) activities allows for the extension of the radiotherapeutic cascade. Studies conducted in vivo and in vitro demonstrated that the combination of CuPy-Au@EM and moderate dose RT (4 Gy) can significantly reduce tumor proliferation. These findings indicated that CuPy-Au@EM nanospheres could be plausibly developed into promising radio-sensitizers on tumors.","A multifunctional nanozyme that mimics tumor cell exosomes (CuPy-Au@EM) was fabricated in this work for achieving a highly effective and secure cancer radiotherapy regimen."]

SCI

英语

其他

We are grateful for the financial support from the Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund, Project znpy 2019079 and Discipline Cultivation Funding (Oncology), Zhongnan Hospital of Wuhan University (ZNXKPY2020012)[ZNXKPY2020012] ; Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund[PTXM2022012] ; null[znpy 2019079]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied

WOS:001055812900001

ROYAL SOC CHEMISTRY

Web of Science

1.Wuhan Univ, Zhongnan Hosp, Hubei Ctr Qual Control Radiotherapy Canc, Hubei Canc Clin Study Ctr,Dept Radiat & Med Oncol,, Wuhan 430071, Hubei, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Gastrointes, Shenzhen 518020, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Geriatr, Shenzhen 518020, Guangdong, Peoples R China
4.Wuhan Univ, Sch Phys & Technol, Key Lab Artificial Micro & Nanostruct, Minist Educ, Wuhan 430072, Hubei, Peoples R China

Chen, Gaili,Jiang, Dazhen,Ding, Shuaijie,et al. A tumor cell exosome-mimicking multifunctional nanozyme for targeted breast cancer radiotherapy[J]. NANOSCALE,2023,15(36).

Chen, Gaili,Jiang, Dazhen,Ding, Shuaijie,Huang, Chunyu,Zhu, Daoming,&Jiang, Huangang.(2023).A tumor cell exosome-mimicking multifunctional nanozyme for targeted breast cancer radiotherapy.NANOSCALE,15(36).

Chen, Gaili,et al."A tumor cell exosome-mimicking multifunctional nanozyme for targeted breast cancer radiotherapy".NANOSCALE 15.36(2023).