The physiologic complexity of beat-to-beat blood pressure is associated with age-related alterations in blood pressure regulation

Jiang, Xin1,2,3,9; Mang, Xiaoying1,2,3; Zhou, Huiting1,2,3; Chen, Jingmei1,2,3; Tan, Huiying1,2; Ren, Huixia1,2,3; Huang, Baofeng1,2,3; Zhong, Lilian1,2,3; Lipsitz, Lewis A.4,5,6; Manor, Brad4,5,6; Guo, Yi2,3,7,8,10; Zhou, Junhong4,5,6

2023-08-24

10.1111/acel.13943

AGING CELL   影响因子和分区

1474-9718

1474-9726

The fluctuations in resting-state beat-to-beat blood pressure (BP) are physiologically complex, and the degree of such BP complexity is believed to reflect the multiscale regulation of this critical physiologic process. Hypertension (HTN), one common age-related condition, is associated with altered BP regulation and diminished system responsiveness to perturbations such as orthostatic change. We thus aimed to characterize the impact of HTN on resting-state BP complexity, as well as the relationship between BP complexity and both adaptive capacity and underlying vascular characteristics. We recruited 392 participants (age: 60-91 years), including 144 that were normotensive and 248 with HTN (140 controlled- and 108 uncontrolled-HTN). Participants completed a 10-min continuous finger BP recording during supine rest, then underwent measures of lying-to-standing BP change, arterial stiffness (i.e., brachial-ankle pulse wave velocity), and endothelial function (i.e., flow-mediated vasodilation). The complexity of supine beat-to-beat systolic (SBP) and diastolic (DBP) BP was quantified using multiscale entropy. Thirty participants with HTN (16 controlled-HTN and 14 uncontrolled-HTN) exhibited orthostatic hypotension. SBP and DBP complexity was greatest in normotensive participants, lower in those with controlled-HTN, and lowest in those in uncontrolled-HTN (p < 0.0005). Lower SBP and DBP complexity correlated with greater lying-to-standing decrease in SBP and DBP level (beta = -0.33 to -0.19, p < 0.01), greater arterial stiffness (beta = -0.35 to -0.18, p < 0.01), and worse endothelial function (beta = 0.17-0.22, p < 0.01), both across all participants and within the control-and uncontrolled-HTN groups. These results suggest that in older adults, BP complexity may capture the integrity of multiple interacting physiologic mechanisms that regulate BP and are important to cardiovascular health.

beat-to-beat blood pressure hypertension multiscale entropy orthostatic BP change physiological complexity

SCI

英语

通讯

"Five Threes" clinical research program of Shenzhen People's Hospital[SYWGSLCYJ202204] ; Basic Research Project of Shenzhen Natural Science Foundation[JCYJ20190807145209306] ; National Institute on Aging[1K01AG075180-01] ; Natural Science Foundation of Guangdong Province[2021A1515010983] ; Shenzhen Key Medical Discipline Construction Fund["SZXK005","SZXK012"] ; Sustainable Development Science and Technology Project of Shenzhen Science and Technology Innovation Commission["KCXFZ20201221173400001","KCXFZ20201221173411032"]

Cell Biology ; Geriatrics & Gerontology

Cell Biology ; Geriatrics & Gerontology

WOS:001053851000001

WILEY

MOLECULAR BIOLOGY & GENETICS

Web of Science

1.Shenzhen Peoples Hosp, Dept Geriatr, Shenzhen, Peoples R China
2.Jinan Univ, Clin Med Coll 2, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Peoples R China
4.Hebrew Sr Life, Hinda & Arthur Marcus Inst Aging Res, Boston, MA USA
5.Beth Israel Deaconess Med Ctr, Div Gerontol, Boston, MA USA
6.Harvard Med Sch, Boston, MA USA
7.Shenzhen Peoples Hosp, Dept Neurol, Shenzhen, Peoples R China
8.Shenzhen Bay Lab, Shenzhen, Peoples R China
9.Shenzhen Peoples Hosp, Dept Geriatr, Shenzhen, Guangdong, Peoples R China
10.Shenzhen Peoples Hosp, Dept Neurol, Shenzhen, Guangdong, Peoples R China

Jiang, Xin,Mang, Xiaoying,Zhou, Huiting,et al. The physiologic complexity of beat-to-beat blood pressure is associated with age-related alterations in blood pressure regulation[J]. AGING CELL,2023.

Jiang, Xin.,Mang, Xiaoying.,Zhou, Huiting.,Chen, Jingmei.,Tan, Huiying.,...&Zhou, Junhong.(2023).The physiologic complexity of beat-to-beat blood pressure is associated with age-related alterations in blood pressure regulation.AGING CELL.

Jiang, Xin,et al."The physiologic complexity of beat-to-beat blood pressure is associated with age-related alterations in blood pressure regulation".AGING CELL (2023).