Clinical features and transmission risk analysis of dengue virus infections in Shenzhen, During 2014-2019

Ye, Guoguo1,2; Xu, Zhixiang3; Yang, Minghui3,4,5,6; Wang, Jun1; Liang, Jinhu1,2; Yin, Juzhen1,2; Yang, Yang1,2; Xia, Han7; Liu, Yingxia1,2

2023

10.1016/j.csbj.2023.07.001

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL   影响因子和分区

2001-0370

Dengue fever (DF) and dengue hemorrhagic fever (DHF) are among the most common tropical diseases affecting humans. To analyze the risk of clinical and transmission of DF/DHF in Shenzhen, the surveillance on patients of all-age patients with dengue virus (DENV) infections was conducted. Our findings revealed that the majority of DENV-infected patients are young to middle-aged males, and the development of the disease is accompanied by abnormal changes in the percentages of neutrophils, lymphocytes, and basophils. Demographic analysis revealed that these patients is concentrated in areas such as Futian District, which may be due to the higher mosquito density and temperature than that in other area. Subsequent, mosquito infection experiments confirmed that the effect of temperature shift on DENV proliferation and transmission. Not only that, constant temperatures can enhance the spread of DENV, even increase the risk of epidemic. Thus, the role of innate immune response should be highlighted in the prediction of severe severity of DENV-infected patients, and temperature should be taken into account in the prevention and control of DENV.Introduction: Dengue fever (DF) and dengue hemorrhagic fever (DHF) are among the most common tropical diseases affecting humans, and which caused by the four dengue virus serotypes (DENV 1-4). Objectives: To analyze the risk of clinical and transmission of DF/DHF in Shenzhen.Methods: The surveillance on patients of all-age patients with dengue virus (DENV) infections was conducted.Results: Our findings revealed that the majority of DENV-infected patients are young to middle-aged males, and the development of the disease is accompanied by abnormal changes in the percentages of neutrophils, lym-phocytes, and basophils. Demographic analysis revealed that these patients is concentrated in areas such as Futian District, which may be due to the higher mosquito density and temperature than that in other area. Subsequent, mosquito infection experiments confirmed that the effect of temperature shift on DENV proliferation and transmission. Not only that, constant temperatures can enhance the spread of DENV, even increase the risk of epidemic. Conclusion: 1. Elevated levels of neutrophils, lymphocytes, basophils, and temperature are all significant risk factors for dengue transmission and pathogenesis; 2. Temperature increasing is associated with a higher risk of dengue transmission; 3. Fluctuations in temperature around 28 degrees C (28 & PLUSMN; 5 degrees C) would increase dengue transmission.

DENV Temperature Innate immune

SCI ; EI

英语

第一 ; 通讯

National Science and Technology Major Project[2021YFC2301803] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties[SZGSP011] ; Shenzhen Natural Science Foundation[JCYJ20190809152415652] ; scientific research project of Shenzhen Third People's Hospital[G2022032]

Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology

Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology

WOS:001054891100001

ELSEVIER

20233114480425

Lymphocytes ; Population statistics ; Risk assessment ; Tropics

Meteorology:443 ; Immunology:461.9.1 ; Thermodynamics:641.1 ; Accidents and Accident Prevention:914.1

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Shenzhen Key Lab Pathogen & Immun,Div Infect Dis,, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Sch Med, Shenzhen, Peoples R China
3.Univ Chinese Acad Sci, Savaid Med Sch, Beijing, Peoples R China
4.Beijing Inst Technol, Key Lab Med Mol Sci & Pharmaceut Engn, Beijing 100081, Peoples R China
5.Beijing Inst Technol, Key Lab Mol Med & Biotherapy, Sch Life Sci, Beijing 100081, Peoples R China
6.Beijing Inst Technol, Adv Res Inst Multidisciplinary Sci, Beijing 100081, Peoples R China
7.Chinese Acad Sci, Wuhan Inst Virol, Ctr Biosafety Mega Sci, Key Lab Special Pathogens & Biosafety, Wuhan, Hubei, Peoples R China

Ye, Guoguo,Xu, Zhixiang,Yang, Minghui,et al. Clinical features and transmission risk analysis of dengue virus infections in Shenzhen, During 2014-2019[J]. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,2023,21:3728-3735.

Ye, Guoguo.,Xu, Zhixiang.,Yang, Minghui.,Wang, Jun.,Liang, Jinhu.,...&Liu, Yingxia.(2023).Clinical features and transmission risk analysis of dengue virus infections in Shenzhen, During 2014-2019.COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL,21,3728-3735.

Ye, Guoguo,et al."Clinical features and transmission risk analysis of dengue virus infections in Shenzhen, During 2014-2019".COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL 21(2023):3728-3735.