南方科技大学知识苑(SUSTech KC): SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis

题名	SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis
作者	Liu, Lihong 1,2; Du, Jie 1; Yang, Sidi 2; Zheng, Birong 1,2; Shen, Jian 4; Huang, Jiacheng 2; Cao, Liu 1; Huang, Siyao 1; Liu, Xue 1; Guo, Liping 5; Li, Chunmei 1; Ke, Changwen 6; Peng, Xiaofang 6; Guo, Deyin 2; Peng, Hong 1,3
通讯作者	Guo, Deyin; Peng, Hong
发表日期	2023-07-01
DOI	10.1016/j.redox.2023.102752
发表期刊	REDOX BIOLOGY 影响因子和分区
ISSN	2213-2317
卷号	63
摘要	Viral infection-induced cell death has long been considered as a double-edged sword in the inhibition or exacerbation of viral infections. Patients with severe Coronavirus Disease 2019 (COVID-19) are characterized by multiple organ dysfunction syndrome and cytokine storm, which may result from SARS-CoV-2-induced cell death. Previous studies have observed enhanced ROS level and signs of ferroptosis in SARS-CoV-2 infected cells or specimens of patients with COVID-19, but the exact mechanism is not clear yet. Here, we find SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis. SARS-CoV-2 ORF3a promotes the degradation of NRF2 through recruiting Keap1, thereby attenuating cellular resistance to oxidative stress and facilitated cells to ferroptotic cell death. Our study uncovers that SARS-CoV-2 ORF3a functions as a positive regulator of ferroptosis, which might explain SARS-CoV-2-induced damage in multiple organs in COVID-19 patients and imply the potential of ferroptosis inhibition in COVID-19 treatment.
关键词	SARS-CoV-2 ORF3a Ferroptosis Keap1 NRF2
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	National Natural Science Foundation of China, China["81620108020","32041002","81702724","32200109"] ; Shenzhen Science and Technology Program, China["JSGG20200225150431472","KQTD20180411143323605","JCYJ20190807161009621","JSGG20220606141003007"]
WOS研究方向	Biochemistry & Molecular Biology
WOS类目	Biochemistry & Molecular Biology
WOS记录号	WOS:001055414500001
出版者	ELSEVIER
来源库	Web of Science
引用统计	被引频次[WOS]：12
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/553566
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Sun Yat Sen Univ, Sch Med, Ctr Infect & Immun Study CIIS, MOE Key Lab Trop Dis Control, Shenzhen Campus, Shenzhen, Peoples R China 2.Guangzhou Lab, Guangzhou, Guangdong, Peoples R China 3.Sun Yat Sen Univ, Sch Med, Shenzhen Key Lab Syst Med Inflammatory Dis, Shenzhen Campus, Shenzhen, Peoples R China 4.Cent Hosp Panyu Dist, Dept Lab Med, Guangzhou, Peoples R China 5.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Hosp 2, Shenzhen, Guangdong, Peoples R China 6.Guangdong Prov Ctr Dis Control & Prevent, Guangzhou, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Liu, Lihong,Du, Jie,Yang, Sidi,et al. SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis[J]. REDOX BIOLOGY,2023,63.
APA	Liu, Lihong.,Du, Jie.,Yang, Sidi.,Zheng, Birong.,Shen, Jian.,...&Peng, Hong.(2023).SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis.REDOX BIOLOGY,63.
MLA	Liu, Lihong,et al."SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis".REDOX BIOLOGY 63(2023).