Bioactive and Biodegradable Polycaprolactone-Based Nanocomposite for Bone Repair Applications

Emadi, Hosein1,2; Karevan, Mehdi2; Masoudi Rad, Maryam3; Sadeghzade, Sorour4; Pahlevanzadeh, Farnoosh5; Khodaei, Mohammad6; Khayatzadeh, Saber7; Lotfian, Saeid8

2023-09-01

10.3390/polym15173617

POLYMERS   影响因子和分区

2073-4360

This study investigated the relationship between the structure and mechanical properties of polycaprolactone (PCL) nanocomposites reinforced with baghdadite, a newly introduced bioactive agent. The baghdadite nanoparticles were synthesised using the sol-gel method and incorporated into PCL films using the solvent casting technique. The results showed that adding baghdadite to PCL improved the nanocomposites' tensile strength and elastic modulus, consistent with the results obtained from the prediction models of mechanical properties. The tensile strength increased from 16 to 21 MPa, and the elastic modulus enhanced from 149 to 194 MPa with fillers compared to test specimens without fillers. The thermal properties of the nanocomposites were also improved, with the degradation temperature increasing from 388 & DEG;C to 402 & DEG;C when 10% baghdadite was added to PCL. Furthermore, it was found that the nanocomposites containing baghdadite showed an apatite-like layer on their surfaces when exposed to simulated body solution (SBF) for 28 days, especially in the film containing 20% nanoparticles (PB20), which exhibited higher apatite density. The addition of baghdadite nanoparticles into pure PCL also improved the viability of MG63 cells, increasing the viability percentage on day five from 103 in PCL to 136 in PB20. Additionally, PB20 showed a favourable degradation rate in PBS solution, increasing mass loss from 2.63 to 4.08 per cent over four weeks. Overall, this study provides valuable insights into the structure-property relationships of biodegradable-bioactive nanocomposites, particularly those reinforced with new bioactive agents.

baghdadite polycaprolactone nanocomposite composite films bone tissue engineering solvent casting method mechanical properties thermal properties biological properties

SCI ; EI

英语

其他

Polymer Science

Polymer Science

WOS:001061283500001

MDPI

20233714718081

Apatite ; Degradation ; Elastic moduli ; Fillers ; Nanocomposite films ; Nanoparticles ; Reinforcement ; Sols ; Tensile strength ; Thermodynamic properties ; Tissue engineering

Biomedical Engineering:461.1 ; Minerals:482.2 ; Thermodynamics:641.1 ; Semiconducting Materials:712.1 ; Nanotechnology:761 ; Chemical Reactions:802.2 ; Chemical Products Generally:804 ; Solid State Physics:933 ; Materials Science:951

Web of Science

1.Univ Tehran, Coll Engn, Sch Mech Engn, Tehran 1417614411, Iran
2.Isfahan Univ Technol, Dept Mech Engn, Esfahan 8415683111, Iran
3.Isfahan Univ Technol, Dept Chem Engn, Esfahan 8415683111, Iran
4.Southern Univ Sci & Technol, Dept Mech & Aerosp Engn, Shenzhen Key Lab Soft Mech & Smart Mfg, Shenzhen 518055, Peoples R China
5.Isfahan Univ Technol, Dept Mat Engn, Esfahan 8415683111, Iran
6.Isfahan Univ Technol, Golpayegan Coll Engn, Mat Engn Grp, Esfahan 8415683111, Iran
7.Univ West England, Dept Engn Design & Math, Bristol BS16 1QY, England
8.Univ Strathclyde, Fac Engn, Glasgow G4 0LZ, Scotland

Emadi, Hosein,Karevan, Mehdi,Masoudi Rad, Maryam,et al. Bioactive and Biodegradable Polycaprolactone-Based Nanocomposite for Bone Repair Applications[J]. POLYMERS,2023,15(17).

Emadi, Hosein.,Karevan, Mehdi.,Masoudi Rad, Maryam.,Sadeghzade, Sorour.,Pahlevanzadeh, Farnoosh.,...&Lotfian, Saeid.(2023).Bioactive and Biodegradable Polycaprolactone-Based Nanocomposite for Bone Repair Applications.POLYMERS,15(17).

Emadi, Hosein,et al."Bioactive and Biodegradable Polycaprolactone-Based Nanocomposite for Bone Repair Applications".POLYMERS 15.17(2023).