Hydro Electroactive Janus Micro/Nano Fiber Dressing with Exudate Management Ability for Wound Healing

Li, Ling1; Zhao, Qian1; Feng, Fan1; Li, Chenglin1; Wang, Tiantian1; Chen, Weichao1; Ren, Xiaochuan1; Huang, Yuesheng2; Li, Jiwei1

2023-09-01

10.1002/admt.202300796

ADVANCED MATERIALS TECHNOLOGIES   影响因子和分区

2365-709X

["Exudate management and bioelectric signals are critical to promoting wound healing. In this study, the thermoplastic polyurethane (TPU) nanofiber is directly electrospun on the cotton microfibers (Cotton) to prepare a Janus dressing (TPU/Cotton), which can unidirectionally drain the excess exudate. Then, Ag/Zn dot electrodes are deposited on the TPU layer, which can produce an electric field penetrating the wound when activated by wound exudate. The hydro-activated Ag/Zn's electrical stimulation (ES) can promote the migration of fibroblast cells and shows excellent antibacterial activity against E. coli and S. aureus. Furthermore, in vivo experiments show that the exudate management coupled with ES accelerated wound healing at multiple stages by promoting re-epithelization, collagen deposition, and vascularization. Moreover, the Ag/Zn@TPU/Cotton dressing shows excellent biocompatibility in the vitro cytotoxicity experiments. These findings may shed some light on developing the next generation of wound dressings with self-activated electrical stimulation and exudate management.","Ag/Zn dots are deposited on the thermoplastic polyurethane (TPU) layer of TPU/cotton nonwovens (Cotton). The hydro-activated Ag/Zn's electrical stimulation (ES) can promote the migration of fibroblast cells and show excellent antibacterial activity against E. coli and S. aureus. The exudate management coupled with ES can accelerate wound healing at multiple stages by promoting re-epithelization, collagen deposition, and vascularization.image"]

cell migration electrical stimulation exudate management Janus dressing wound healing

SCI ; EI

英语

通讯

This work was partially supported by the National Natural Science Foundation of China (52203060), the State Key Development Program for Basic Research of China (2017YFC1103302), the Shandong Provincial Universities Youth Innovation Technology Plan Innovati[2017YFC1103302] ; National Natural Science Foundation of China[2022KJ152] ; State Key Development Program for Basic Research of China[2022M711735] ; null[52203060]

Materials Science

Materials Science, Multidisciplinary

WOS:001058882200001

WILEY

20233614685067

Biocompatibility ; Cell culture ; Electric fields ; Escherichia coli

Immunology:461.9.1 ; Electricity: Basic Concepts and Phenomena:701.1 ; Agricultural Products:821.4

Web of Science

1.Qingdao Univ, Ind Res Inst Nonwovens & Tech Text, Coll Text & Clothing, Sch Basic Med, Qingdao 266071, Peoples R China
2.Southern Univ Sci & Technol, Southern Univ Sci & Technol Hosp, Inst Wound Repair & Regenerat Med, Sch Med,Dept Wound Repair, Shenzhen 518055, Peoples R China

Li, Ling,Zhao, Qian,Feng, Fan,et al. Hydro Electroactive Janus Micro/Nano Fiber Dressing with Exudate Management Ability for Wound Healing[J]. ADVANCED MATERIALS TECHNOLOGIES,2023,8.

Li, Ling.,Zhao, Qian.,Feng, Fan.,Li, Chenglin.,Wang, Tiantian.,...&Li, Jiwei.(2023).Hydro Electroactive Janus Micro/Nano Fiber Dressing with Exudate Management Ability for Wound Healing.ADVANCED MATERIALS TECHNOLOGIES,8.

Li, Ling,et al."Hydro Electroactive Janus Micro/Nano Fiber Dressing with Exudate Management Ability for Wound Healing".ADVANCED MATERIALS TECHNOLOGIES 8(2023).