Combination of bacterial-targeted delivery of gold-based AIEgen radiosensitizer for fluorescence-image-guided enhanced radio-immunotherapy against advanced cancer

Duo，Yanhong1,3; Chen，Zide1,5; Li，Zihuang1; Li，Xing2; Yao，Yaoqiang1; Xu，Tianzhao1; Gao，Ge6; Luo，Guanghong1,3,4,5

2023-12-01

10.1016/j.bioactmat.2023.05.010

Bioactive Materials   影响因子和分区

2452-199X

2452-199X

Aggregation-Induced Emission luminogen (AIEgen) possess great potential in enhancing bioimaging-guided radiotherapeutic effects and radioimmunotherapy to improve the therapeutic effects of the tumor with good biosafety. Bacteria as a natural carrier have demonstrated great advantages in tumor targeted delivery and penetration to tumor. Herein, we construct a delivery platform that Salmonella VNP20009 act as an activated bacteria vector loaded the as-prepared novel AIEgen (TBTP-Au, VNP@TBTP-Au), which showed excellent radio-immunotherapy. VNP@TBTP-Au could target and retain AIEgen at the tumor site and deliver it into tumor cells specially, upon X-ray irradiation, much ROS was generated to induce immunogenic cell death via cGAS-STING signaling pathway to evoke immune response, thus achieving efficient radioimmunotherapy of the primary tumor with good biosafety. More importantly, the radioimmunotherapy with VNP@TBTP-Au formatted good abscopal effect that was able to suppress the growth of distant tumor. Our strategy pioneer a novel and simple strategy for the organic combination of bacteria and imaging-guided radiotherapy, and also pave the foundation for the combination with immunotherapy for better therapeutic effects.

Abscopal effect Aggregation-induced emission Immunogenic cell death Immunotherapy Radiotherapy VNP20009

SCI

英语

第一 ; 通讯

Basic and Applied Basic Research Foundation of Guangdong Province[2022A1515110534];National Natural Science Foundation of China[82102904];Medical Science and Technology Foundation of Guangdong Province[A2022122];Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20190807144605514];Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20190808154213097];Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20210324113405014];Science, Technology and Innovation Commission of Shenzhen Municipality[JCYJ20210324113810029];

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:001087546100001

KEAI PUBLISHING LTD

2-s2.0-85168538376

Scopus

1.Department of Radiation Oncology,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,Guangdong,518020,China
2.School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China
3.Department of Microbiology,Tumor and Cell Biology (MTC),Karolinska Institutet,Stockholm,17177,Sweden
4.Shenzhen Institute of Aggregate Science and Technology,School of Science and Engineering,The Chinese University of Hong Kong,Shenzhen,Guangdong,518172,China
5.Department of Interventional Radiology,Guangdong Provincial People's Hospital,Guangdong Academy of Medical Sciences,Guangzhou,Guangdong,510080,China
6.Department of Laboratory Medicine,The Third Xiangya Hospital,Central South University,Changsha,410013,China

Duo，Yanhong,Chen，Zide,Li，Zihuang,et al. Combination of bacterial-targeted delivery of gold-based AIEgen radiosensitizer for fluorescence-image-guided enhanced radio-immunotherapy against advanced cancer[J]. Bioactive Materials,2023,30:200-213.

Duo，Yanhong.,Chen，Zide.,Li，Zihuang.,Li，Xing.,Yao，Yaoqiang.,...&Luo，Guanghong.(2023).Combination of bacterial-targeted delivery of gold-based AIEgen radiosensitizer for fluorescence-image-guided enhanced radio-immunotherapy against advanced cancer.Bioactive Materials,30,200-213.

Duo，Yanhong,et al."Combination of bacterial-targeted delivery of gold-based AIEgen radiosensitizer for fluorescence-image-guided enhanced radio-immunotherapy against advanced cancer".Bioactive Materials 30(2023):200-213.