New insights into the mechanisms of diabetic kidney disease: Role of circadian rhythm and Bmal1

Peng，Zhimei1,2; Liang，Yanting1; Liu，Xueying2; Shao，Jie1; Hu，Nan2; Zhang，Xinzhou1,2

2023-10-01

10.1016/j.biopha.2023.115422

Biomedicine and Pharmacotherapy   影响因子和分区

0753-3322

1950-6007

It is common for diabetic kidney disease (DKD) to be complicated by abnormal blood glucose, blood lipids, and blood pressure rhythms. Thus, it is essential to examine diagnostic and treatment plans from the perspective of circadian disruption. This brief review discusses the clinical relevance of circadian rhythms in DKD and how the core clock gene encoding brain and muscle arnt-like protein 1 (BMAL1) functions owing to the importance of circadian rhythm disruption processes, including the excretion of urinary protein and irregular blood pressure, which occur in DKD. Exploring Bmal1 and its potential mechanisms and signaling pathways in DKD following contact with Sirt1 and NF-κB is novel and important. Finally, potential pharmacological and behavioral intervention strategies for DKD circadian rhythm disturbance are outlined. This review aids in unveiling novel, potential molecular targets for DKD based on circadian rhythms.

BMAL1 Circadian rhythms Diabetic kidney disease Sirt1

SCI

英语

通讯

Shenzhen Governmental Sustainable Development Fund[KCXFZ20201221173612034] ; Shenzhen Key Laboratory of Kidney Diseases[ZDSYS201504301616234] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Spe-cialties[SZGSP001]

Research & Experimental Medicine ; Pharmacology & Pharmacy

Medicine, Research & Experimental ; Pharmacology & Pharmacy

WOS:001095639000001

ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER

2-s2.0-85169620442

Scopus

1.Department of Nephrology,The Second Clinical College of Jinan University,Shenzhen People's Hospital,Shenzhen,China
2.Shenzhen Key Laboratory of Kidney Diseases,Shenzhen People's Hospital (The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China

Peng，Zhimei,Liang，Yanting,Liu，Xueying,et al. New insights into the mechanisms of diabetic kidney disease: Role of circadian rhythm and Bmal1[J]. Biomedicine and Pharmacotherapy,2023,166.

Peng，Zhimei,Liang，Yanting,Liu，Xueying,Shao，Jie,Hu，Nan,&Zhang，Xinzhou.(2023).New insights into the mechanisms of diabetic kidney disease: Role of circadian rhythm and Bmal1.Biomedicine and Pharmacotherapy,166.

Peng，Zhimei,et al."New insights into the mechanisms of diabetic kidney disease: Role of circadian rhythm and Bmal1".Biomedicine and Pharmacotherapy 166(2023).