南方科技大学知识苑(SUSTech KC): Rapidly in situ forming an injectable Chitosan/PEG hydrogel for intervertebral disc repair

题名	Rapidly in situ forming an injectable Chitosan/PEG hydrogel for intervertebral disc repair
作者	Huang，Lin1 ; Wang，Wantao 1,2; Xian，Yiwen1 ; Liu，Lei1 ; Fan，Jinghao 1; Liu，Hongmei1 ; Zheng，Zhaomin 2; Wu，Decheng1
通讯作者	Liu，Hongmei; Zheng，Zhaomin; Wu，Decheng
发表日期	2023-10-01
DOI	10.1016/j.mtbio.2023.100752
发表期刊	Materials Today Bio 影响因子和分区
ISSN	2590-0064
EISSN	2590-0064
卷号	22
摘要	Intervertebral disc (IVD) degeneration occurred with the increasing age or accidents has puzzled peoples in daily life. To seal IVD defect by injectable hydrogels is a promising method for slowing down IVD degeneration. Herein, we reported a rapidly in situ forming injectable chitosan/PEG hydrogel (CSMA-PEGDA-L) through integrating photo-crosslink of methacrylate chitosan (CSMA) with Schiff base reaction between CSMA and aldehyde polyethylene glycol (PEGDA). The CSMA-PEGDA-L possessed a stronger compressive strength than the photo-crosslinked CSMA-L hydrogel and Schiff-base-crosslinked CSMA-PEGDA hydrogel. This chitosan/PEG hydrogel showed low cytotoxicity from incubation experiments of nucleus pulpous cells. When implanted on the punctured IVD of rat's tail, the CSMA-PEGDA-L hydrogel could well retard the progression of IVD degeneration through physical plugging, powerfully proven by radiological and histological evaluations. This work demonstrated the strategy of in situ injectable glue may be a potential solution for prevention of IVD degeneration.
关键词	Chitosan Injectable hydrogel Intervertebral disc repair PEG Tissue engineering
相关链接	[Scopus记录]
收录类别	SCI ; EI
语种	英语
学校署名	第一 ; 通讯
资助项目	Ministry of Science and Technology of the People's Republic of China[2020YFA0908900];National Natural Science Foundation of China[21725403];National Natural Science Foundation of China[21935011];Shenzhen Fundamental Research Program[JCYJ20220530114409020];Science, Technology and Innovation Commission of Shenzhen Municipality[JSGG20200225151916021];Science, Technology and Innovation Commission of Shenzhen Municipality[KQTD20200820113012029];
WOS研究方向	Engineering ; Materials Science
WOS类目	Engineering, Biomedical ; Materials Science, Biomaterials
WOS记录号	WOS:001050497800001
出版者	ELSEVIER
EI入藏号	20233114476412
EI主题词	Carrier sense multiple access ; Compressive strength ; Hydrogels ; Tissue engineering
EI分类号	Biomedical Engineering:461.1 ; Colloid Chemistry:801.3 ; Chemical Products Generally:804 ; Organic Compounds:804.1
Scopus记录号	2-s2.0-85166265270
来源库	Scopus
引用统计	被引频次[WOS]：15
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/559576
专题	工学院_生物医学工程系
作者单位	1.Guangdong Provincial Key Laboratory of Advanced Biomaterials,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China 2.Department of Spine Surgery,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,510275,China
第一作者单位	生物医学工程系
通讯作者单位	生物医学工程系
第一作者的第一单位	生物医学工程系
推荐引用方式 GB/T 7714	Huang，Lin,Wang，Wantao,Xian，Yiwen,et al. Rapidly in situ forming an injectable Chitosan/PEG hydrogel for intervertebral disc repair[J]. Materials Today Bio,2023,22.
APA	Huang，Lin.,Wang，Wantao.,Xian，Yiwen.,Liu，Lei.,Fan，Jinghao.,...&Wu，Decheng.(2023).Rapidly in situ forming an injectable Chitosan/PEG hydrogel for intervertebral disc repair.Materials Today Bio,22.
MLA	Huang，Lin,et al."Rapidly in situ forming an injectable Chitosan/PEG hydrogel for intervertebral disc repair".Materials Today Bio 22(2023).