南方科技大学知识苑(SUSTech KC): Patient-Derived Organoids as a Promising Tool for Multimodal Management of Sarcomas

题名	Patient-Derived Organoids as a Promising Tool for Multimodal Management of Sarcomas
作者	Xu，Songfeng 1,2; Tan，Shih Jye 3; Guo，Ling2,3
通讯作者	Tan，Shih Jye; Guo，Ling
发表日期	2023-09-01
DOI	10.3390/cancers15174339
发表期刊	Cancers 影响因子和分区
EISSN	2072-6694
卷号	15 期号:17
摘要	The management of sarcomas, a diverse group of cancers arising from connective tissues, presents significant challenges due to their heterogeneity and limited treatment options. Patient-derived sarcoma organoids (PDSOs) have emerged as a promising tool in the multimodal management of sarcomas, offering unprecedented opportunities for personalized medicine and improved treatment strategies. This review aims to explore the potential of PDSOs as a promising tool for multimodal management of sarcomas. We discuss the establishment and characterization of PDSOs, which realistically recapitulate the complexity and heterogeneity of the original tumor, providing a platform for genetic and molecular fidelity, histological resemblance, and functional characterization. Additionally, we discuss the applications of PDSOs in pathological and genetic evaluation, treatment screening and development, and personalized multimodal management. One significant advancement of PDSOs lies in their ability to guide personalized treatment decisions, enabling clinicians to assess the response and efficacy of different therapies in a patient-specific manner. Through continued research and development, PDSOs hold the potential to revolutionize sarcoma management and drive advancements in personalized medicine, biomarker discovery, preclinical modeling, and therapy optimization. The integration of PDSOs into clinical practice can ultimately improve patient outcomes and significantly impact the field of sarcoma treatment.
关键词	patient-derived organoids personalized medicine sarcomas
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	Chongqing Postdoctoral Science Foundation[82273308];
WOS研究方向	Oncology
WOS类目	Oncology
WOS记录号	WOS:001062407000001
出版者	MDPI
Scopus记录号	2-s2.0-85170381057
来源库	Scopus
引用统计	被引频次[WOS]：6
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/559640
专题	生命科学学院_生物系生命科学学院前沿与交叉科学研究院南方科技大学医学院
作者单位	1.National Cancer Center/National Clinical Research Center for Cancer,Cancer Hospital & Shenzhen Hospital,Chinese Academy of Medical Science,Peking Union Medical College,Shenzhen,518116,China 2.Department of Orthopedics,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital,Chinese Academy of Medical Science,Peking Union Medical College,Beijing,100021,China 3.Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Department of Biology,Academy for Advanced Interdisciplinary Studies,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Blvd, Biology Building 402,518055,China
通讯作者单位	生物系; 南方科技大学医学院; 前沿与交叉科学研究院; 生命科学学院
推荐引用方式 GB/T 7714	Xu，Songfeng,Tan，Shih Jye,Guo，Ling. Patient-Derived Organoids as a Promising Tool for Multimodal Management of Sarcomas[J]. Cancers,2023,15(17).
APA	Xu，Songfeng,Tan，Shih Jye,&Guo，Ling.(2023).Patient-Derived Organoids as a Promising Tool for Multimodal Management of Sarcomas.Cancers,15(17).
MLA	Xu，Songfeng,et al."Patient-Derived Organoids as a Promising Tool for Multimodal Management of Sarcomas".Cancers 15.17(2023).