Towards the total synthesis of aleurodiscal

Zhao，Hai Xiao; Xu，Jing

2023-07-28

10.1016/j.tetlet.2023.154613

Tetrahedron Letters   影响因子和分区

0040-4039

1873-3581

Aleurodiscal is one of the representative members of the isopropyl trans-hydrindane sesterterpenoid family. Herein, we describe our efforts towards the synthesis of a complex sesterterpenoid, aleurodiscal. The key precursor of the Cope rearrangement was concisely synthesized from a known bicyclic starting material in 13 linear steps. Our approach highlighted a Van Leusen homologation reaction and an oxidative rearrangement of a tertiary carbinol.

Aleurodiscal Cope rearrangement Sesterterpenoids Total synthesis trans-hydrindane

SCI ; IC ; CCR

英语

第一 ; 通讯

NSFC["21971104","22271136"] ; Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis[ZDSYS20190902093215877] ; Guangdong Provincial Key Laboratory of Catalysis[2020B121201002] ; Guangdong Innovative Program[2019BT02Y335] ; Key research projects in colleges and universities in Guangdong Province[2021ZDZX2035] ; Shenzhen Nobel Prize Scientists Laboratory Project[C17783101] ; Innovative Team of Universities in Guangdong Province[2020KCXTD016] ; Guangdong Natural Science Foundation[2022A1515010456]

Chemistry

Chemistry, Organic

WOS:001035716900001

PERGAMON-ELSEVIER SCIENCE LTD

CHEMISTRY

2-s2.0-85163158673

Scopus

Shenzhen Grubbs Institute and Department of Chemistry and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis,Southern University of Science and Technology,Shenzhen,518055,China

Zhao，Hai Xiao,Xu，Jing. Towards the total synthesis of aleurodiscal[J]. Tetrahedron Letters,2023,125.

Zhao，Hai Xiao,&Xu，Jing.(2023).Towards the total synthesis of aleurodiscal.Tetrahedron Letters,125.

Zhao，Hai Xiao,et al."Towards the total synthesis of aleurodiscal".Tetrahedron Letters 125(2023).