Gold Nanoparticles: Construction for Drug Delivery and Application in Cancer Immunotherapy

Huang，Huiqun1,2; Liu，Ronghui3; Yang，Jie2; Dai，Jing2; Fan，Shuhao4; Pi，Jiang4; Wei，Yubo5; Guo，Xinrong1,2

2023-07-01

10.3390/pharmaceutics15071868

Pharmaceutics   影响因子和分区

1999-4923

Cancer immunotherapy is an innovative treatment strategy to enhance the ability of the immune system to recognize and eliminate cancer cells. However, dose limitations, low response rates, and adverse immune events pose significant challenges. To address these limitations, gold nanoparticles (AuNPs) have been explored as immunotherapeutic drug carriers owing to their stability, surface versatility, and excellent optical properties. This review provides an overview of the advanced synthesis routes for AuNPs and their utilization as drug carriers to improve precision therapies. The review also emphasises various aspects of AuNP-based immunotherapy, including drug loading, targeting strategies, and drug release mechanisms. The application of AuNPs combined with cancer immunotherapy and their therapeutic efficacy are briefly discussed. Overall, we aimed to provide a recent understanding of the advances, challenges, and prospects of AuNPs for anticancer applications.

cancer immunotherapy drug delivery gold nanoparticles

SCI

英语

其他

Basic and Applied Basic Research Foundation of Guangdong Province[2021A1515110843];Basic and Applied Basic Research Foundation of Guangdong Province[2022A1515140191];National Natural Science Foundation of China[22265016];School of Traditional Chinese Medicine, Guangdong Pharmaceutical University[GDMUB2021004];

WOS:001038825300001

2-s2.0-85166349069

Scopus

1.Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics,The First Dongguan Affiliated Hospital,Guangdong Medical University,Dongguan,523808,China
2.Dongguan Key Laboratory of Environmental Medicine,School of Public Health,Guangdong Medical University,Dongguan,523808,China
3.School of Microelectronic,Southern University of Science and Technology,Shenzhen,518000,China
4.Institute of Laboratory Medicine,School of Medical Technology,Guangdong Medical University,Dongguan,523808,China
5.Yunnan Key Laboratory of Pharmacology for Natural Products,School of Pharmaceutical Sciences,Kunming Medical University,Kunming,650500,China

Huang，Huiqun,Liu，Ronghui,Yang，Jie,et al. Gold Nanoparticles: Construction for Drug Delivery and Application in Cancer Immunotherapy[J]. Pharmaceutics,2023,15(7).

Huang，Huiqun.,Liu，Ronghui.,Yang，Jie.,Dai，Jing.,Fan，Shuhao.,...&Guo，Xinrong.(2023).Gold Nanoparticles: Construction for Drug Delivery and Application in Cancer Immunotherapy.Pharmaceutics,15(7).

Huang，Huiqun,et al."Gold Nanoparticles: Construction for Drug Delivery and Application in Cancer Immunotherapy".Pharmaceutics 15.7(2023).