Joint association of physical activity and sleep duration with risk of all-cause and cause-specific mortality: a population-based cohort study using accelerometry

Liang，Yannis Yan1,2; Feng，Hongliang1; Chen，Yilin1,2; Jin，Xinyi1; Xue，Huachen3; Zhou，Mingqing4; Ma，Huan2; Ai，Sizhi3; Wing，Yun Kwok5; Geng，Qingshan1,6; Zhang，Jihui3,4,5,7

2023-07-01

10.1093/eurjpc/zwad060

European Journal of Preventive Cardiology   影响因子和分区

2047-4873

2047-4881

Aims To investigate the joint association of accelerometer-measured physical activity (PA) and sleep duration with mortality risk. Methods and results A 7-day accelerometer recording was performed on 92 221 participants (age 62.4 ± 7.8 years; 56.4% women) from the UK Biobank between February 2013 and December 2015. We divided sleep duration into three groups (short, normal, and long), total volume of PA into three levels according to tertiles (high, intermediate, low), and moderate-to-vigorous PA (MVPA) into two groups based on the World Health Organization guidelines. The mortality outcomes were prospectively collected through the death registry. Over a median follow-up of 7.0 years, 3080 adults died, of which 1074 died from cardiovascular disease (CVD) and 1871 from cancer. The associations of PA and sleep duration with mortality risk were all in a curvilinear dose–response pattern (P <0.001). PA and sleep duration had additive and multiplicative interactions on mortality risk (P <0.05). Compared with the participants with guideline-recommended MVPA and normal sleep duration, those without recommended MVPA but having short or long sleep duration were at a higher risk for all-cause mortality [short sleep: hazard ratio (HR) = 1.88; 95% confidence interval (CI), 1.61–2.20; long sleep: HR = 1.69; 95% CI, 1.49–1.90]. A higher volume of PA or recommended MVPA attenuated the detrimental effects of short or long sleep duration on all-cause and CVD mortality risks. Conclusion MVPA meeting recommendations or a higher volume of PA at any intensity potentially diminished the adverse effects on all-cause and cause-specific mortality associated with short and long sleep duration. All-cause and cause-specific mortality risks associated with accelerometer-measured short or long sleep duration were attenuated by physical activity (PA). Both accelerometer-measured short and long sleep duration were associated with higher risk for all-cause and CVD mortality. Either a higher volume of PA or moderate-to-vigorous PA reaching the WHO-recommended level, as was also measured with accelerometer, attenuated the excessive mortality risks associated with short or long sleep duration.

Accelerometer Mortality Physical activity Sleep duration UK Biobank

SCI

英语

通讯

National Natural Science Foundation of China[82101558];

Cardiovascular System & Cardiology

Cardiac & Cardiovascular Systems

WOS:001184990800001

OXFORD UNIV PRESS

2-s2.0-85161461441

Scopus

1.Guangdong Cardiovascular Institute,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Guangzhou,106 Zhongshaner Road, Guangdong,519041,China
2.Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention,Guangdong Cardiovascular Institute,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Southern Medical University,Guangzhou,106 Zhongshaner Road, Guangdong,519041,China
3.Center for Sleep and Circadian Medicine,The Affiliated Brain Hospital of Guangzhou Medical University,Guangzhou,36 Mingxin Road, Guangdong,510370,China
4.Guangdong Mental Health Center,Guangdong Provincial People’s Hospital,Guangdong Academy of Medical Sciences,Southern Medical University,Guangzhou,102 Zhongshan Road, Guangdong,510180,China
5.Li Chiu Kong Family Sleep Assessment Unit,Department of Psychiatry,Faculty of Medicine,The Chinese University of Hong Kong,Shatin,33 A Kung Kok Street,999077,Hong Kong
6.Department of Geriatrics,Shenzhen People’s Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,1017 Dongmen North Road, Guangdong,518020,China
7.Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application,Guangzhou,106 Zhongshaner Road, Guangdong,510180,China

Liang，Yannis Yan,Feng，Hongliang,Chen，Yilin,et al. Joint association of physical activity and sleep duration with risk of all-cause and cause-specific mortality: a population-based cohort study using accelerometry[J]. European Journal of Preventive Cardiology,2023,30(9):832-843.

Liang，Yannis Yan.,Feng，Hongliang.,Chen，Yilin.,Jin，Xinyi.,Xue，Huachen.,...&Zhang，Jihui.(2023).Joint association of physical activity and sleep duration with risk of all-cause and cause-specific mortality: a population-based cohort study using accelerometry.European Journal of Preventive Cardiology,30(9),832-843.

Liang，Yannis Yan,et al."Joint association of physical activity and sleep duration with risk of all-cause and cause-specific mortality: a population-based cohort study using accelerometry".European Journal of Preventive Cardiology 30.9(2023):832-843.