Ultra-stable MOF@MOF nanoplatform for photodynamic therapy sensitized by relieved hypoxia due to mitochondrial respiration inhibition

Yu，Jiantao; Li，Qing; Wei，Zixiang; Fan，Guiling; Wan，Feiyan; Tian，Leilei

2023

10.1016/j.actbio.2023.08.025

Acta Biomaterialia   影响因子和分区

1742-7061

1878-7568

Metal-organic frameworks (MOFs) with periodically arranged porphyrinic linkers avoiding the self-quenching issue of porphyrins in photodynamic therapy (PDT) have been widely applied. However, the porphyrinic MOFs still face challenges of poor stability under physiological conditions and limited photodynamic efficiency by the hypoxia condition of tumors. Herein, we fabricate the MOF@MOF structure with a protective MOF shell to improve the stability and relieve the hypoxia condition of tumors for sensitized PDT. Under protection of the MOF shell, the MOF@MOF structure can keep intact for 96 h under physiological conditions. Consequently, the tumoral accumulation efficiency is two folds of the MOF core. Furthermore, the MOF shell decomposes under acidic environment, and the loaded inhibitor of mitochondria pyruvate carrier (7-amino carboxycoumarins-2, 7ACC2) will be released. 7ACC2 inhibits the mitochondrial pyruvate influx and simultaneously blocks glucose and lactate from fueling the mitochondrial respiration, thereupon relieving the hypoxia condition of tumors. Under a 5-min laser irradiation, the 7ACC2 carrying MOF@MOF nanoplatforms induced doubled cellular apoptosis and reduced 70% of the tumor growth compared with the cargo-free MOF@MOF. In summary, the design of this stable and hypoxia self-relievable MOF@MOF nanoplatform will enlighten the future development of MOF-based nanomedicines and PDT. Statement of significance: Though widely used for photodynamic therapy (PDT) in previous studies, porphyrinic metal-organic frameworks (MOFs) still face challenges in poor stability under physiological conditions and limited photodynamic efficiency due to the hypoxia condition of tumors. In order to solve these problems, (1) we develop the MOF@MOF strategy to improve the physiological stability; (2) an inhibitor of mitochondria pyruvate carrier, 7-amino carboxycoumarins-2 (7ACC2), is loaded to inhibit the mitochondrial pyruvate influx and simultaneously block glucose and lactate from fueling the mitochondrial respiration, thereupon relieving the hypoxia condition of tumors. In comparison with previous studies, our strategy simultaneously improves stability and overcomes the limited PDT efficiency in the hypoxia tumor tissue, which will enlighten the future development of MOF-based nanomedicines and PDT.

Aerobic respiration Hypoxia Metal-organic framework Photodynamic therapy Physiological stability

SCI ; EI

英语

第一 ; 通讯

National Natural Science Foundation of China[51973089];Science, Technology and Innovation Commission of Shenzhen Municipality[KQTD20170810111314625];

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:001088717900001

ELSEVIER SCI LTD

20233514659029

Cell death ; Efficiency ; Glucose ; Metal-Organic Frameworks ; Mitochondria ; Organic polymers ; Photodynamic therapy ; Physiology ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Biology:461.9 ; Metallurgy:531.1 ; Organic Compounds:804.1 ; Organic Polymers:815.1.1 ; Production Engineering:913.1

2-s2.0-85169046178

Scopus

Department of Materials Science and Engineering,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Blvd., Nanshan District,518055,China

Yu，Jiantao,Li，Qing,Wei，Zixiang,et al. Ultra-stable MOF@MOF nanoplatform for photodynamic therapy sensitized by relieved hypoxia due to mitochondrial respiration inhibition[J]. Acta Biomaterialia,2023,170:330-343.

Yu，Jiantao,Li，Qing,Wei，Zixiang,Fan，Guiling,Wan，Feiyan,&Tian，Leilei.(2023).Ultra-stable MOF@MOF nanoplatform for photodynamic therapy sensitized by relieved hypoxia due to mitochondrial respiration inhibition.Acta Biomaterialia,170,330-343.

Yu，Jiantao,et al."Ultra-stable MOF@MOF nanoplatform for photodynamic therapy sensitized by relieved hypoxia due to mitochondrial respiration inhibition".Acta Biomaterialia 170(2023):330-343.