南方科技大学知识苑(SUSTech KC): The role of E3 ubiquitin ligases in bone homeostasis and related diseases

题名	The role of E3 ubiquitin ligases in bone homeostasis and related diseases
作者	Dong，Yuechao; Chen，Yangshan; Ma，Guixing ; Cao，Huiling
通讯作者	Cao，Huiling
发表日期	2023
DOI	10.1016/j.apsb.2023.06.016
发表期刊	Acta Pharmaceutica Sinica B 影响因子和分区
ISSN	2211-3835
EISSN	2211-3843
卷号	13 期号:10
摘要	The ubiquitin–proteasome system (UPS) dedicates to degrade intracellular proteins to modulate demic homeostasis and functions of organisms. These enzymatic cascades mark and modifies target proteins diversly through covalently binding ubiquitin molecules. In the UPS, E3 ubiquitin ligases are the crucial constituents by the advantage of recognizing and presenting proteins to proteasomes for proteolysis. As the major regulators of protein homeostasis, E3 ligases are indispensable to proper cell manners in diverse systems, and they are well described in physiological bone growth and bone metabolism. Pathologically, classic bone-related diseases such as metabolic bone diseases, arthritis, bone neoplasms and bone metastasis of the tumor, etc., were also depicted in a UPS-dependent manner. Therefore, skeletal system is versatilely regulated by UPS and it is worthy to summarize the underlying mechanism. Furthermore, based on the current status of treatment, normal or pathological osteogenesis and tumorigenesis elaborated in this review highlight the clinical significance of UPS research. As a strategy possibly remedies the limitations of UPS treatment, emerging PROTAC was described comprehensively to illustrate its potential in clinical application. Altogether, the purpose of this review aims to provide more evidence for exploiting novel therapeutic strategies based on UPS for bone associated diseases.
关键词	Bone resorption Chondrocyte E3 ubiquitin ligase Osteoblast Osteoclast Osteogenesis PROTAC UPS
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Natural Science Foundation of China["82022047","81972100"] ; National Key Research and Development Program of China[2019YFA0906001] ; Guangdong Provincial Science and Technology Innovation Council, China[2017B030301018]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
WOS记录号	WOS:001140354800001
出版者	INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
Scopus记录号	2-s2.0-85168432898
来源库	Scopus
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/560134
专题	南方科技大学医学院_生物化学系南方科技大学医学院
作者单位	Department of Biochemistry,School of Medicine,Southern University of Science and Technology,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Key University Laboratory of Metabolism and Health of Guangdong,Shenzhen,518055,China
第一作者单位	生物化学系; 南方科技大学医学院
通讯作者单位	生物化学系; 南方科技大学医学院
第一作者的第一单位	生物化学系; 南方科技大学医学院
推荐引用方式 GB/T 7714	Dong，Yuechao,Chen，Yangshan,Ma，Guixing,et al. The role of E3 ubiquitin ligases in bone homeostasis and related diseases[J]. Acta Pharmaceutica Sinica B,2023,13(10).
APA	Dong，Yuechao,Chen，Yangshan,Ma，Guixing,&Cao，Huiling.(2023).The role of E3 ubiquitin ligases in bone homeostasis and related diseases.Acta Pharmaceutica Sinica B,13(10).
MLA	Dong，Yuechao,et al."The role of E3 ubiquitin ligases in bone homeostasis and related diseases".Acta Pharmaceutica Sinica B 13.10(2023).