Nuts consumption and hypertension risks in children: a mediating role of circulating lipid metabolites

Qin，Liu1; Ren，Yanling1; Chen，Lan1; Feng，Ye1; Luo，Shunqing1; Zhang，Ping1; Zhang，Wei2; Liang，Xiaohua1

2023

10.1080/10641963.2023.2243056

Clinical and Experimental Hypertension   影响因子和分区

1064-1963

1525-6006

Background: Although nuts play an important role in preventing cardiovascular disease, the metabolic cues by which nuts regulate blood pressure have not been fully understood.Aims:We conducted a nested case–control study in a prospective cohort study of Southwest China children to explore the potential lipid metabolites related to the relationship between nut dietary and blood pressure. Methods: Forty-three hypertension cases and 53 controls serum samples were obtained for lipidomic data analysis using a liquid chromatography mass spectrometry platform. Results: We identified four lipid metabolites that are associated with nut intake by a generalized linear model and logistic regression analysis, including phosphatidylglycerol 43:6 [PG (43:6)], phosphatidylcholine 18:0/20:3 [PC (18:0/20:3)], and two phosphatidylethanolamine (PE) compounds [PE (P-16:0/20:4) and PE (P-22:0/18:2)]. Logistic regression analysis indicated that the levels of PG (43:6) and PE (P-16:0/20:4) were negatively associated with hypertension in children, which might be useful biomarkers for predicting childhood hypertension. Further mediation analysis revealed that PG (43:6) and PC (18:0/20:3) function as mediating variables between nut intake and blood pressure levels. Conclusion: This study provides scientific evidence that nut consumption induces some beneficial changes in lipid metabolism, which may reduce the risk of hypertension in children.

children diet hypertension lipid metabolite Nuts

SCI

英语

其他

Pharmacology & Pharmacy ; Cardiovascular System & Cardiology

Pharmacology & Pharmacy ; Peripheral Vascular Disease

WOS:001043140700001

TAYLOR & FRANCIS INC

PHARMACOLOGY & TOXICOLOGY

2-s2.0-85166785438

Scopus

1.Department of Clinical Epidemiology and Biostatistics,Children’s Hospital of Chongqing Medical University,National Clinical Research Center for Child Health and Disorders,Ministry of Education Key Laboratory of Child Development and Disorders,Chongqing Key Laboratory of Pediatrics,Chongqing,China
2.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,Guangdong,China

Qin，Liu,Ren，Yanling,Chen，Lan,et al. Nuts consumption and hypertension risks in children: a mediating role of circulating lipid metabolites[J]. Clinical and Experimental Hypertension,2023,45(1).

Qin，Liu.,Ren，Yanling.,Chen，Lan.,Feng，Ye.,Luo，Shunqing.,...&Liang，Xiaohua.(2023).Nuts consumption and hypertension risks in children: a mediating role of circulating lipid metabolites.Clinical and Experimental Hypertension,45(1).

Qin，Liu,et al."Nuts consumption and hypertension risks in children: a mediating role of circulating lipid metabolites".Clinical and Experimental Hypertension 45.1(2023).