南方科技大学知识苑(SUSTech KC): Antiviral activity and active components of the leaves from Sabia parviflora Wall. ex Roxb

题名	Antiviral activity and active components of the leaves from Sabia parviflora Wall. ex Roxb
作者	Zhou，Yongqiang 1; Li，Sumei 2; Pan，Bowen 1; Xiao，Junwei 1; Tang，Tingting 1; Xie，Shouxia 2; Yang，Xin 1; Wu，Guihui 3; Xiao，Jinxin 3; Yang，Jian 4; Zhou，Ying 1; Pang，Yuxin 1; Wei，Ying 1
通讯作者	Zhou，Ying
发表日期	2023
DOI	10.1080/14786419.2023.2239995
发表期刊	Natural Product Research 影响因子和分区
ISSN	1478-6419
EISSN	1478-6427
摘要	Sabia parviflora (SP, “xiao hua qing feng teng” in Chinese) was recorded as an important ethnic medicine to be used for treating viral hepatitis. The antiviral activity of four SP extracts and potent antiviral compounds evaluated with cathepsin L protease (Cat L PR) and HIV-1 protease (HIV-1 PR). UPLC-HRMS was used for identifying the bioactive components. In addition, the possible inhibitory mechanism of the identified compounds on viral protease was further discussed by molecular docking. As a result, four extracts of SP exhibited inhibitory activity of HIV-1 PR and Cat L PR with IC range from 0.015 to 0.80 mg/mL. Meanwhile, six compounds inhibited HIV-1 PR with IC range from 0.032 to 0.80 mg/mL. Moreover, procyanidin B2 had good affinity for HIV-1 PR and CatL PR protein, respectively. These findings suggest S. parviflora leaves can be used for treating HIV and procyanidin B2 may play a role in antiviral protease.
关键词	active component molecular docking protease Sabia parviflora wall UPLC-HRMS
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	Innovation Group Project of Guizhou Province[3411-4110000520364] ; Association of Natural Science of Foundation of China[SZXK059] ; Research Center of Molecular Bioactivity from Traditional Chinese Medicine and Ethnomedicine[2023A13] ; Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties[Qian Ke He Zhi cheng [2020] 4Y213] ; Bright Future Fund for Guangdong Provincial Hospital Pharmacology Research[Qian Ke He Foundation ZK [2021] General 518] ; null[Qian Jiao He KY [2021] 018] ; null[81760758]
WOS研究方向	Chemistry ; Pharmacology & Pharmacy
WOS类目	Chemistry, Applied ; Chemistry, Medicinal
WOS记录号	WOS:001040680100001
出版者	TAYLOR & FRANCIS LTD
ESI学科分类	PHARMACOLOGY & TOXICOLOGY
Scopus记录号	2-s2.0-85166767259
来源库	Scopus
引用统计	被引频次[WOS]：0
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/560179
专题	南方科技大学医学院_药理学系南方科技大学第一附属医院
作者单位	1.College of Pharmacy,Guizhou University of Traditional Chinese Medicine,Guiyang,China 2.Department of Pharmacology,Shenzhen People’s Hospital (The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology),Shenzhen,China 3.Guizhou Bailing Group Pharmaceutical Co.,Ltd,Ansun,China 4.College of Pharmacy and Nutrition,University of Saskatchewan,Saskatoon,Canada
推荐引用方式 GB/T 7714	Zhou，Yongqiang,Li，Sumei,Pan，Bowen,et al. Antiviral activity and active components of the leaves from Sabia parviflora Wall. ex Roxb[J]. Natural Product Research,2023.
APA	Zhou，Yongqiang.,Li，Sumei.,Pan，Bowen.,Xiao，Junwei.,Tang，Tingting.,...&Wei，Ying.(2023).Antiviral activity and active components of the leaves from Sabia parviflora Wall. ex Roxb.Natural Product Research.
MLA	Zhou，Yongqiang,et al."Antiviral activity and active components of the leaves from Sabia parviflora Wall. ex Roxb".Natural Product Research (2023).