Gelable and Adhesive Powder for Lethal Non-Compressible Hemorrhage Control

Zhang，Kaiwen1; Xian，Yiwen1; Li，Ming2; Pan，Zheng1; Zhu，Ziran1,3; Yang，Yu1; Wang，Hufei3; Zhang，Licheng2; Zhang，Chong1; Wu，Decheng1

2023

10.1002/adfm.202305222

Advanced Functional Materials   影响因子和分区

1616-301X

1616-3028

Hemostatic powders are widely used in clinical and emergency situations but often exhibit low wet adhesion, cytotoxicity concerns, and do not work well for lethal non-compressible hemorrhage. Here a new kind of gelable and adhesive powder (GAP) is developed, which integrates chitosan microspheres (CM), tetra-armed poly(ethylene glycol) amine (Tetra-PEG-NH), and tetra-armed poly(ethylene glycol) succinimidyl succinate (Tetra-PEG-SS). Upon application to the wound site, the macroporous CM can rapidly absorb the interfacial liquids, and meanwhile, the hydrated GAP turns into hydrogel (crosslinking between Tetra-PEG-SS and CM/Tetra-PEG-NH) with stable and robust adhesion to the wet tissue though covalent bonding. The in vitro and in vivo results suggest that the GAP with optimized formulation exhibits strong tissue adhesive, high burst pressure, and enhanced blood clotting ability, as well as excellent biocompatibility and on-demand removal properties. A significantly improved hemostatic efficacy is demonstrated in the rat liver, spleen, and femoral artery injury models compared to that of the CM, commercial fibrin glue, and Yunnan Baiyao (YB). The GAP can also halt the severe bleeding from pig visceral organs. Overall, the proposed GAP has many advantages including good biocompatibility, rapid and effective hemostasis, low cost, and ease of use, making it as a promising hemostat for lethal non-compressible hemorrhage control.

chitosan microspheres hemostatic powders non-compressible hemorrhage self-gelation tetra-PEG hydrogels wound sealing

SCI ; EI

英语

NI论文

第一 ; 通讯

Ministry of Science and Technology of China[2020YFA0908900] ; National Natural Science Foundation of China["21935011","21725403"] ; Shenzhen Science and Technology Innovation Commission["KQTD20200820113012029","JCYJ20220818100601003"] ; Guangdong Basic and Applied Basic Research Foundation[2022A1515110321] ; Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:001040535700001

WILEY-V C H VERLAG GMBH

20233214492516

Adhesion ; Adhesives ; Biocompatibility ; Chitosan ; Ethylene glycol ; Gelation ; Hydrogels ; Mammals ; Microspheres ; Polyethylene glycols ; Polyols

Immunology:461.9.1 ; Colloid Chemistry:801.3 ; Chemical Operations:802.3 ; Chemical Products Generally:804 ; Organic Compounds:804.1 ; Organic Polymers:815.1.1 ; Materials Science:951

MATERIALS SCIENCE

2-s2.0-85166517370

Scopus

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No.1088 Xueyuan Avenue, Nanshan, Guangdong,518055,China
2.Senior Department of Orthopedics,National Clinical Research Center for Orthopedics,Sports Medicine and Rehabilitation,Chinese PLA General Hospital,Beijing,100853,China
3.Beijing National Laboratory for Molecular Sciences,Institute of Chemistry,Chinese Academy of Sciences,Beijing,100190,China

Zhang，Kaiwen,Xian，Yiwen,Li，Ming,et al. Gelable and Adhesive Powder for Lethal Non-Compressible Hemorrhage Control[J]. Advanced Functional Materials,2023,33.

Zhang，Kaiwen.,Xian，Yiwen.,Li，Ming.,Pan，Zheng.,Zhu，Ziran.,...&Wu，Decheng.(2023).Gelable and Adhesive Powder for Lethal Non-Compressible Hemorrhage Control.Advanced Functional Materials,33.

Zhang，Kaiwen,et al."Gelable and Adhesive Powder for Lethal Non-Compressible Hemorrhage Control".Advanced Functional Materials 33(2023).