Crosstalk between m6A and coding/non-coding RNA in cancer and detection methods of m6A modification residues

Meng，Qingren1; Schatten，Heide2; Zhou，Qian3; Chen，Jun1

2023

10.18632/aging.204836

Aging   影响因子和分区

1945-4589

N6-methyladenosine (m6A) is one of the most common and well-known internal RNA modifications that occur on mRNAs or ncRNAs. It affects various aspects of RNA metabolism, including splicing, stability, translocation, and translation. An abundance of evidence demonstrates that m6A plays a crucial role in various pathological and biological processes, especially in tumorigenesis and tumor progression. In this article, we introduce the potential functions of m6A regulators, including “writers” that install m6A marks, “erasers” that demethylate m6A, and “readers” that determine the fate of m6A-modified targets. We have conducted a review on the molecular functions of m6A, focusing on both coding and noncoding RNAs. Additionally, we have compiled an overview of the effects noncoding RNAs have on m6A regulators and explored the dual roles of m6A in the development and advancement of cancer. Our review also includes a detailed summary of the most advanced databases for m6A, state-of-the-art experimental and sequencing detection methods, and machine learning-based computational predictors for identifying m6A sites.

detection method m6A database N6-methyladenosine (m6A) RNA modification tumor

SCI

英语

第一 ; 通讯

funds for the construction of key medical disciplines in Shenzhen[SZXK076]

Cell Biology ; Geriatrics & Gerontology

Cell Biology ; Geriatrics & Gerontology

WOS:001035308800034

IMPACT JOURNALS LLC

2-s2.0-85165993240

Scopus

1.National Clinical Research Center for Infectious Diseases,Shenzhen Third People’s Hospital,The Second Hospital Affiliated with the Southern University of Science and Technology,Shenzhen,Guangdong Province,China
2.Department of Veterinary Pathobiology,University of Missouri,Columbia,65211,United States
3.International Cancer Center,Shenzhen University Medical School,Shenzhen,Guangdong Province,China

Meng，Qingren,Schatten，Heide,Zhou，Qian,et al. Crosstalk between m6A and coding/non-coding RNA in cancer and detection methods of m6A modification residues[J]. Aging,2023,15(13):6577-6619.

Meng，Qingren,Schatten，Heide,Zhou，Qian,&Chen，Jun.(2023).Crosstalk between m6A and coding/non-coding RNA in cancer and detection methods of m6A modification residues.Aging,15(13),6577-6619.

Meng，Qingren,et al."Crosstalk between m6A and coding/non-coding RNA in cancer and detection methods of m6A modification residues".Aging 15.13(2023):6577-6619.