南方科技大学知识苑(SUSTech KC): Research progress of Gasdermin D Gasdermin D 蛋白的研究进展

题名	Research progress of Gasdermin D Gasdermin D 蛋白的研究进展
作者	Li，Chen Guang 1,2; Mai，Feng Yi 3 ; Liang，Jing Rong 1,2; Xiao，Li Zu 1,2; Zhang，Zhi Guo 1
发表日期	2023
DOI	10.12360/CPB202202015
发表期刊	Chinese Pharmacological Bulletin 影响因子和分区
ISSN	1001-1978
卷号	39 期号:5页码:817-822
摘要	Pyroptosis is a novel process of programmed inflammatory necrosis, which is closely related to microbial infections and autoimmune diseases. In recent years it has been proved that Gasdermin D is an executive protein of pyroptosis. Cleaved Gasdermin D leads to the formation of pores in cell membrane to induce pyroptosis, and the release of inflammatory factors such as IL-1β and IL-18 aggravates the occurrence of inflammatory responses. With the deepening of Gasdermin D research, it is gradually clear its protein structure and activation sites, which has other activation pathways apart from inducing inflammasome activation. Activation of Gasdermin D does not necessarily mean cell death, even if it could induce the formation of pores in cell membrane and regulation of inflammatory cytokine secretion. These findings offer insight into Gasdermin D function and change our understanding of pyroptosis and programmed necrosis. The recent progress of Gasdermin D is highlighted in this review.
关键词	Gasdermin D Gasdermin family inflammation inflammsome pyroptosis
相关链接	[Scopus记录]
语种	中文
学校署名	其他
Scopus记录号	2-s2.0-85165646815
来源库	Scopus
引用统计	被引频次[WOS]：0
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/560210
专题	南方科技大学
作者单位	1.Shenzhen University,Health Science Center,School of Biomedical Engineering,Shenzhen,518060,China 2.Pain Management,Huazhong University of Science and Technology Union Shenzhen Hospital,Shenzhen,518052,China 3.Dept of Medicine,Southern University of Science and Technology,Shenzhen,518055,China
推荐引用方式 GB/T 7714	Li，Chen Guang,Mai，Feng Yi,Liang，Jing Rong,等. Research progress of Gasdermin D Gasdermin D 蛋白的研究进展[J]. Chinese Pharmacological Bulletin,2023,39(5):817-822.
APA	Li，Chen Guang,Mai，Feng Yi,Liang，Jing Rong,Xiao，Li Zu,&Zhang，Zhi Guo.(2023).Research progress of Gasdermin D Gasdermin D 蛋白的研究进展.Chinese Pharmacological Bulletin,39(5),817-822.
MLA	Li，Chen Guang,et al."Research progress of Gasdermin D Gasdermin D 蛋白的研究进展".Chinese Pharmacological Bulletin 39.5(2023):817-822.