Serum Uric Acid Levels Are Associated With Macula Microvasculature Changes In Hypertensive White Matter Hyperintensity Patients

Wei，Ruili1; Xie，Jianyang2; Meng，Fangxia1; He，Fangping1; Liu，Jiang3; Zhao，Yitian2; Liang，Hui1

2023

10.2174/1567202620666221027095220

Current Neurovascular Research   影响因子和分区

1567-2026

1875-5739

Purpose: To characterize the macula microvasculature using fractal dimension (FD) in hypertensive white matter hyperintensity (WMH) participants and explore the association between the microvascular changes and serum uric acid levels. Methods: Thirty-eight WMH participants were dementia and stroke-free, and 37 healthy controls were enrolled. Optical coherence tomographic angiography (OCTA) was used to image the superficial vascular complex (SVC), deep vascular complex (DVC), and inner vascular complex (IVC) in a 2.5-mm diameter concentric circle (excluding the foveal avascular zone FAZ). A commercial algo-rithm was used to quantify the complexity and density of the three capillary layers by fractal analy-sis. Results: WMH participants showed significantly lower FD value in the SVC (P = 0.002), DVC (P < 0.001) and IVC (P = 0.012) macula microvasculature compared with control group. After adjusting for risk factors (hypertension, diabetes, age and gender) SVC (P = 0.035) and IVC (P = 0.030) significantly correlated with serum uric acid. Conclusion: Serum uric acid levels are associated with microvascular changes in WMH. Fractal dimension based on OCTA imaging could help quantitatively characterize the macula microvascula-ture changes in WMH and may be a potential screening tool to detect serum uric acid level changes.

Fazekas scale macula microvascula-ture optical coherence tomography Serum uric acid white matter hyperintensity

SCI

英语

其他

Neurosciences & Neurology

Clinical Neurology ; Neurosciences

WOS:001033497600015

BENTHAM SCIENCE PUBL LTD

NEUROSCIENCE & BEHAVIOR

2-s2.0-85164116987

Scopus

1.Department of Neurology,First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,79 Qingchun Road,310003,China
2.Cixi Institute of Biomedical Engineering,Ningbo Institute of Materials Technology and Engineer-ing,Chinese Academy of Sciences,Ningbo,China
3.Department of Computer Science and Engineering,Southern University of Science and Technology,Shenzhen,China

Wei，Ruili,Xie，Jianyang,Meng，Fangxia,et al. Serum Uric Acid Levels Are Associated With Macula Microvasculature Changes In Hypertensive White Matter Hyperintensity Patients[J]. Current Neurovascular Research,2023,20(1):132-139.

Wei，Ruili.,Xie，Jianyang.,Meng，Fangxia.,He，Fangping.,Liu，Jiang.,...&Liang，Hui.(2023).Serum Uric Acid Levels Are Associated With Macula Microvasculature Changes In Hypertensive White Matter Hyperintensity Patients.Current Neurovascular Research,20(1),132-139.

Wei，Ruili,et al."Serum Uric Acid Levels Are Associated With Macula Microvasculature Changes In Hypertensive White Matter Hyperintensity Patients".Current Neurovascular Research 20.1(2023):132-139.