| 题名 | Current landscape and future prospects of RET and ROS1 targets |
| 作者 | |
| 通讯作者 | Zhang, Hai-Long |
| 发表日期 | 2023-09-01
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| DOI | |
| 发表期刊 | |
| ISSN | 2046-8954
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| EISSN | 2046-8962
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| 卷号 | 12期号:3 |
| 摘要 | RET and ROS1 are becoming key targets for targeted therapy. To show current landscape of ROS1 and RET targets, a patent analysis was performed. The present results indicated that inhibitor structures of ROS1 target demonstrated unique elements compared with inhibitor structures of RET or BRAF targets. Our study was the first time to uncover that a number of inhibitor structures of ROS1 target contained sulfur and boron elements. The inhibitors of RET target could be developed for treatment of various cancers, including lung cancer, thyroid cancer, and other solid tumor, while the inhibitors of ROS1 target are virtually developed for treatment of lung cancer. Our findings provide a new insight for drug discovery of ROS1 and RET target. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 其他
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| WOS研究方向 | Pharmacology & Pharmacy
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| WOS类目 | Pharmacology & Pharmacy
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| WOS记录号 | WOS:001062410400002
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 |
被引频次[WOS]：1
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| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/567785 |
| 专题 | 理学院_化学系 |
| 作者单位 | 1.Cent Int Intellectual Property Baotou Co Ltd, Baotou 014030, Peoples R China 2.Southern Univ Sci & Technol, Coll Sci, Dept Chem, Shenzhen 518055, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Zhang, Hai-Long,Kong, Qian. Current landscape and future prospects of RET and ROS1 targets[J]. PHARMACEUTICAL PATENT ANALYST,2023,12(3).
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| APA |
Zhang, Hai-Long,&Kong, Qian.(2023).Current landscape and future prospects of RET and ROS1 targets.PHARMACEUTICAL PATENT ANALYST,12(3).
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| MLA |
Zhang, Hai-Long,et al."Current landscape and future prospects of RET and ROS1 targets".PHARMACEUTICAL PATENT ANALYST 12.3(2023).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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