A novel vanadium complex VO(p-dmada) inhibits neuroinflammation induced by lipopolysaccharide

He, Zhijun1,2; Li, Xiaoqian1; Zhang, Huajie1; Liu, Xin5,6; Han, Shuangxue1; Abdurahman, Anwar1; Shen, Liming1; Du, Xiubo1,3; Li, Nan1,7; Yang, Xiaoda4; Liu, Qiong1,3

2023-10-01

10.1016/j.cclet.2023.108236

CHINESE CHEMICAL LETTERS   影响因子和分区

1001-8417

1878-5964

Uncontrolled microglial activation is decisively involved in the neuroinflammatory pathogenesis of brain diseases. Consequently, suppression of microglial overactivation appears to be a strategy for the prevention of nerve injury. In this paper, a novel vanadium complex, vanadyl N -( p-N,N dimethylaminophenylcarbamoylmethyl)iminodiacetate (VO(p-dmada)), was synthesized from vanadyl sulfate and N,N -dimethyl-p-phenylenediamine, which was structurally characterized by Fourier transform infrared spectrum and ESI-MS analysis. The effect of VO(p-dmada) on neuroinflammation was investigated by using the models of lipopolysaccharide (LPS)-induced BV2 microglial cells and BALB/c mice. Our data demonstrated that VO(p-dmada) significantly suppressed microglial activation by downregulating inflammatory mediators and associated proteins, and inactivating nuclear factor-kappa B (NF-kappa B) signaling pathway. VO(p-dmada) also upregulated peroxisome proliferator activated receptor gamma (PPAR gamma ) by reducing transglutaminase 2 and heat shock protein 60 expression. Co-treatment with PPAR gamma antagonist GW9662 significantly impeded the inhibitory effect of VO(p-dmada) on LPS-induced neuroinflammation. These cumulative findings demonstrated that VO(p-dmada) is a potential new drug for the treatment of neuroinflammation-related neurodegenerative diseases. (c) 2023 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.

Vanadium VanadylN-(p-N,N-dimethylaminophenylcarbamoylmethyl)iminodiacetate (VO(p-dmada)) Neuroinflammation Microglia Proteomics Peroxisome proliferator activated receptor gamma(PPAR gamma)

SCI

英语

其他

National Natural Science Foundation of China[21877081] ; China Postdoctoral Science Foundation[2021M692210] ; Guangdong Provincial Key ST Program[2018B030336001] ; Shenzhen Science and Technology Innovation Commission[JCYJ20200109110001818] ; Shenzhen-Hong Kong Institute of brain Science-Shenzhen Fundamental Research institutions[2022SHIBS0003]

Chemistry

Chemistry, Multidisciplinary

WOS:001062992000001

ELSEVIER SCIENCE INC

CHEMISTRY

Web of Science

1.Shenzhen Univ, Coll Life Sci & Oceanog, Shenzhen Key Lab Marine Biotechnol & Ecol, Shenzhen 518055, Peoples R China
2.Wuhan Polytech Univ, Natl R&D Ctr Se Rrich Agr Prod Proc, Hubei Engn Res Ctr Deep Proc Green Se Rich Agr Pro, Sch Modern Ind Selenium Sci & Engn, Wuhan 430023, Peoples R China
3.Shenzhen Bay Lab, Shenzhen 518055, Peoples R China
4.Peking Univ, Sch Pharmaceut Sci, Dept Chem Biol, State Key Labs Nat & Biomimet Drugs,Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Jinan Univ, Shenzhen Peoples Hosp, Dept Pharm, Clin Med Coll 2, Shenzhen 518020, Peoples R China
6.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Peoples R China
7.Shenzhen Fundamental Res Inst, Shenzhen Hong Kong Inst Brain Sci, Shenzhen 518055, Peoples R China

He, Zhijun,Li, Xiaoqian,Zhang, Huajie,et al. A novel vanadium complex VO(p-dmada) inhibits neuroinflammation induced by lipopolysaccharide[J]. CHINESE CHEMICAL LETTERS,2023,34(10).

He, Zhijun.,Li, Xiaoqian.,Zhang, Huajie.,Liu, Xin.,Han, Shuangxue.,...&Liu, Qiong.(2023).A novel vanadium complex VO(p-dmada) inhibits neuroinflammation induced by lipopolysaccharide.CHINESE CHEMICAL LETTERS,34(10).

He, Zhijun,et al."A novel vanadium complex VO(p-dmada) inhibits neuroinflammation induced by lipopolysaccharide".CHINESE CHEMICAL LETTERS 34.10(2023).