南方科技大学知识苑(SUSTech KC): Chemoselective and Divergent Synthesis of Chlorohydrins and Oxaheterocycles via Ir-Catalyzed Asymmetric Hydrogenation

题名	Chemoselective and Divergent Synthesis of Chlorohydrins and Oxaheterocycles via Ir-Catalyzed Asymmetric Hydrogenation
作者	Zong, Yan1,2 ; Zou, Xiaomei1,2 ; Song, Jingyuan1,2 ; Chen, Gen-Qiang1,2,3 ; Zhang, Xumu1,2
通讯作者	Chen, Gen-Qiang; Zhang, Xumu
发表日期	2023-09-01
DOI	10.1021/acs.orglett.3c02565
发表期刊	ORGANIC LETTERS 影响因子和分区
ISSN	1523-7060
EISSN	1523-7052
卷号	25 期号:37
摘要	Chlorohydrins and oxaheterocycles are synthetically valuable building blocks for diverse natural products and therapeutic substances. A highly efficient Ir/f-phamidol-catalyzed asymmetric hydrogenation of ?-chloroketones was successfully developed, and various chlorohydrins and oxaheterocycles were obtained divergently with excellent yields and enantioselectivities (up to >99% yield and >99% ee). Synthetic utilities of this divergent transformation were demonstrated by gram-scale synthesis of key intermediates of several enantiomerically enriched drugs via this catalytic methodology.
相关链接	[来源记录]
收录类别	SCI ; IC ; CCR
语种	英语
重要成果	NI论文
学校署名	第一 ; 通讯
资助项目	National Key R&D Program of China[2021YFA1500201] ; Shenzhen Science and Technology Innovation Committee["KQTD20150717103157174","JCYJ20210324104202007"] ; Stable Support Plan Program of Shenzhen Natural Science Fund[20200925161222002] ; Key-Area Research and Development Program of Guangdong Province[2020B010188001] ; Innovative Team of Universities in Guangdong Province[2020KCXTD016] ; National Natural Science Foundation of China["21991113","21901107","22171129"] ; Guangdong Basic and Applied Basic Research Foundation[2022B1515020055] ; China Postdoctoral Science Foundation[2023M731516]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:001066346500001
出版者	AMER CHEMICAL SOC
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/571835
专题	理学院_化学系前沿与交叉科学研究院
作者单位	1.Southern Univ Sci & Technol, Dept Chem, Shenzhen Key Lab Small Mol Drug Discovery & Synth, Shenzhen 518055, Peoples R China 2.Southern Univ Sci & Technol, Med Pingshan, Shenzhen 518000, Peoples R China 3.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518000, Peoples R China
第一作者单位	化学系; 南方科技大学
通讯作者单位	化学系; 南方科技大学; 前沿与交叉科学研究院
第一作者的第一单位	化学系
推荐引用方式 GB/T 7714	Zong, Yan,Zou, Xiaomei,Song, Jingyuan,et al. Chemoselective and Divergent Synthesis of Chlorohydrins and Oxaheterocycles via Ir-Catalyzed Asymmetric Hydrogenation[J]. ORGANIC LETTERS,2023,25(37).
APA	Zong, Yan,Zou, Xiaomei,Song, Jingyuan,Chen, Gen-Qiang,&Zhang, Xumu.(2023).Chemoselective and Divergent Synthesis of Chlorohydrins and Oxaheterocycles via Ir-Catalyzed Asymmetric Hydrogenation.ORGANIC LETTERS,25(37).
MLA	Zong, Yan,et al."Chemoselective and Divergent Synthesis of Chlorohydrins and Oxaheterocycles via Ir-Catalyzed Asymmetric Hydrogenation".ORGANIC LETTERS 25.37(2023).