Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms

Zhong, Yixiu1; Zhang, Youfan2; Yu, Aijiao3,4; Zhang, Zhiwen3,4; Deng, Zhenjun1; Xiong, Kaifen5; Wang, Qi2; Zhang, Jianglin1

2023-09-12

10.3389/fphys.2023.1247734

FRONTIERS IN PHYSIOLOGY   影响因子和分区

1664-042X

Exosomes, ranging from 40 to 160 nm in diameter, are extracellular lipid bilayer microvesicles that regulate the body's physiological and pathological processes and are secreted by cells that contain proteins, nucleic acids, amino acids and other metabolites. Previous studies suggested that mesenchymal stem cell (MSC)-derived exosomes could either suppress or support keloid and hypertrophic scar progression. Although previous research has identified the potential value of MSC-exosomes in keloid and hypertrophic scar, a comprehensive analysis of different sources of MSC-exosome in keloid and hypertrophic scar is still lacking. This review mainly discusses different insights regarding the roles of MSC-exosomes in keloid and hypertrophic scar treatment and summarizes possible underlying mechanisms.

exosomes conditioned medium mesenchymal stem cell keloid hypertrophic scar

SCI

英语

第一 ; 通讯

This work was supported by the National Natural Science Foundation of China (82073019, 82073018, and 82202851), Shenzhen Science and Technology Innovation Commission, China (Natural Science Foundation of Shenzhen), (JCYJ20210324113001005, JCYJ2021032411421["82073019","82073018","82202851"] ; National Natural Science Foundation of China["JCYJ20210324113001005","JCYJ20210324114212035","JCYJ20220530151817038"]

Physiology

Physiology

WOS:001070515500001

FRONTIERS MEDIA SA

Web of Science

1.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Dermatol,Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
2.Southern Med Univ, Nanfang Hosp, Dept Dermatol, Guangzhou, Peoples R China
3.Southern Med Univ, Dermatol Hosp, Dept Dermatol, Guangzhou, Peoples R China
4.Southern Med Univ, Nanfang Hosp, Dept Dermatol & Venereol, Guangzhou, Peoples R China
5.Cent South Univ, Xiangya Hosp, Dept Dermatol, Changsha, Hunan, Peoples R China

Zhong, Yixiu,Zhang, Youfan,Yu, Aijiao,et al. Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms[J]. FRONTIERS IN PHYSIOLOGY,2023,14.

Zhong, Yixiu.,Zhang, Youfan.,Yu, Aijiao.,Zhang, Zhiwen.,Deng, Zhenjun.,...&Zhang, Jianglin.(2023).Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms.FRONTIERS IN PHYSIOLOGY,14.

Zhong, Yixiu,et al."Therapeutic role of exosomes and conditioned medium in keloid and hypertrophic scar and possible mechanisms".FRONTIERS IN PHYSIOLOGY 14(2023).